Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease

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Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease. / Kutumova, Elena; Kiselev, Ilya; Sharipov, Ruslan et al.

In: Frontiers in Physiology, Vol. 12, 746300, 11.11.2021.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{6a4dd9797a3648a0956e0a52ef8a66d8,

title = "Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease",

abstract = "Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model{\textquoteright}s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.",

keywords = "agent-based model, blood pressure regulation, cardiovascular system, mathematical modeling, modular model, renal system",

author = "Elena Kutumova and Ilya Kiselev and Ruslan Sharipov and Galina Lifshits and Fedor Kolpakov",

note = "This study was funded in part by the Sirius University of Science and Technology. Publisher Copyright: Copyright {\textcopyright} 2021 Kutumova, Kiselev, Sharipov, Lifshits and Kolpakov.",

year = "2021",

month = nov,

day = "11",

doi = "10.3389/fphys.2021.746300",

language = "English",

volume = "12",

journal = "Frontiers in Physiology",

issn = "1664-042X",

publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease

AU - Kutumova, Elena

AU - Kiselev, Ilya

AU - Sharipov, Ruslan

AU - Lifshits, Galina

AU - Kolpakov, Fedor

PY - 2021/11/11

Y1 - 2021/11/11

N2 - Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.

AB - Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.

KW - agent-based model

KW - blood pressure regulation

KW - cardiovascular system

KW - mathematical modeling

KW - modular model

KW - renal system

UR - http://www.scopus.com/inward/record.url?scp=85120406826&partnerID=8YFLogxK

U2 - 10.3389/fphys.2021.746300

DO - 10.3389/fphys.2021.746300

M3 - Article

C2 - 34867451

AN - SCOPUS:85120406826

VL - 12

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 746300

ER -

ID: 34908645