The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns. / Costa, Fabiano V.; Rosa, Luiz V.; Quadros, Vanessa A. et al.
In: Current Neuropharmacology, Vol. 20, No. 3, 03.2022, p. 476-493.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns
AU - Costa, Fabiano V.
AU - Rosa, Luiz V.
AU - Quadros, Vanessa A.
AU - de Abreu, Murilo S.
AU - Santos, Adair R.S.
AU - Sneddon, Lynne U.
AU - Kalueff, Allan V.
AU - Rosemberg, Denis B.
N1 - Funding Information: F.V.C., V.A.Q., and L.C.R. received CAPES fellowship. D.B.R. and A.R.S. are recipients of CNPq research productivity grant. D.B.R. research is also supported by PROEX/CAPES (process number 23038.005450/2020-19) and Programa PQ-Ga?cho FAPERGS (process number 19/2551-0001764-2) fellowship grants. A.V.K. is the Chair of the International Zebrafish Neuroscience Research Con sortium (ZNRC). His research is supported by the Russian Science Foundation (RSF) grant 20-65-46006. L.U.S. is convenor of the FELASA working group producing a report on Pain Management in Zebrafish and is a member of the NC3Rs (UK) expert panel on zebrafish welfare. The funders did not influence writing and submission of this manuscript. Funding Information: The authors thank the financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-Finance Code 001, and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS). AVK collaboration is supported by Sirius University, Sochi, Russia. Publisher Copyright: © 2022 Bentham Science Publishers.
PY - 2022/3
Y1 - 2022/3
N2 - The ability of the nervous system to detect a wide range of noxious stimuli is crucial to avoid life-threatening injury and to trigger protective behavioral and physiological responses. Pain represents a complex phenomenon, including nociception associated with cognitive and emotional processing. Animal experimental models have been developed to understand the mechanisms involved in pain response, as well as to discover novel pharmacological and non-pharmacological anti-pain therapies. Due to the genetic tractability, similar physiology, low cost, and rich behavioral repertoire, the zebrafish (Danio rerio) is a powerful aquatic model for modeling pain responses. Here, we summarize the molecular machinery of zebrafish responses to painful stimuli, as well as emphasize how zebrafish-based pain models have been successfully used to understand specific molecular, physiological, and behavioral changes following different algogens and/or noxious stimuli (e.g., acetic acid, formalin, histamine, Complete Freund's Adjuvant, cinnamaldehyde, allyl isothiocyanate, and fin clipping). We also discuss recent advances in zebrafish-based studies and outline the potential advantages and limitations of the existing models to examine the mechanisms underlying pain responses from evolutionary and translational perspectives. Finally, we outline how zebrafish models can represent emergent tools to explore pain behaviors and pain-related mood disorders, as well as to facilitate analgesic therapy screening in translational pain research.
AB - The ability of the nervous system to detect a wide range of noxious stimuli is crucial to avoid life-threatening injury and to trigger protective behavioral and physiological responses. Pain represents a complex phenomenon, including nociception associated with cognitive and emotional processing. Animal experimental models have been developed to understand the mechanisms involved in pain response, as well as to discover novel pharmacological and non-pharmacological anti-pain therapies. Due to the genetic tractability, similar physiology, low cost, and rich behavioral repertoire, the zebrafish (Danio rerio) is a powerful aquatic model for modeling pain responses. Here, we summarize the molecular machinery of zebrafish responses to painful stimuli, as well as emphasize how zebrafish-based pain models have been successfully used to understand specific molecular, physiological, and behavioral changes following different algogens and/or noxious stimuli (e.g., acetic acid, formalin, histamine, Complete Freund's Adjuvant, cinnamaldehyde, allyl isothiocyanate, and fin clipping). We also discuss recent advances in zebrafish-based studies and outline the potential advantages and limitations of the existing models to examine the mechanisms underlying pain responses from evolutionary and translational perspectives. Finally, we outline how zebrafish models can represent emergent tools to explore pain behaviors and pain-related mood disorders, as well as to facilitate analgesic therapy screening in translational pain research.
KW - Anti-pain medication screening
KW - Nociceptors
KW - Non-traditional pain models
KW - Noxious stimuli
KW - Pain-related behaviors
KW - Zebrafish
KW - Animals
KW - Analgesics
KW - Zebrafish/genetics
KW - Pain/drug therapy
KW - Translational Research, Biomedical
KW - Disease Models, Animal
UR - http://www.scopus.com/inward/record.url?scp=85126831080&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/acfb71d4-1506-39b6-9221-03ebf1628c58/
U2 - 10.2174/1570159X19666210311104408
DO - 10.2174/1570159X19666210311104408
M3 - Review article
C2 - 33719974
AN - SCOPUS:85126831080
VL - 20
SP - 476
EP - 493
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1570-159X
IS - 3
ER -
ID: 35769889