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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. / Mallick, Swapan; Li, Heng; Lipson, Mark et al.

In: Nature, Vol. 538, No. 7624, 2016, p. 201-206.

Research output: Contribution to journal › Article › peer-review

Harvard

Mallick, S, Li, H, Lipson, M, Mathieson, I, Gymrek, M, Racimo, F, Zhao, M, Chennagiri, N, Nordenfelt, S, Tandon, A, Skoglund, P, Lazaridis, I, Sankararaman, S, Fu, Q, Rohland, N, Renaud, G, Erlich, Y, Willems, T, Gallo, C, Spence, JP, Song, YS, Poletti, G, Balloux, F, Van Driem, G, De Knijff, P, Romero, IG, Jha, AR, Behar, DM, Bravi, CM, Capelli, C, Hervig, T, Moreno-Estrada, A, Posukh, OL, Balanovska, E, Balanovsky, O, Karachanak-Yankova, S, Sahakyan, H, Toncheva, D, Yepiskoposyan, L, Tyler-Smith, C, Xue, Y, Abdullah, MS, Ruiz-Linares, A, Beall, CM, Di Rienzo, A, Jeong, C, Starikovskaya, EB, Metspalu, E, Parik, J, Villems, R, Henn, BM, Hodoglugil, U, Mahley, R, Sajantila, A, Stamatoyannopoulos, G, Wee, JTS, Khusainova, R, Khusnutdinova, E, Litvinov, S, Ayodo, G, Comas, D, Hammer, MF, Kivisild, T, Klitz, W, Winkler, CA, Labuda, D, Bamshad, M, Jorde, LB, Tishkoff, SA, Watkins, WS, Metspalu, M, Dryomov, S, Sukernik, R, Singh, L, Thangaraj, K, Paäbo, S, Kelso, J, Patterson, N & Reich, D 2016, 'The Simons Genome Diversity Project: 300 genomes from 142 diverse populations', Nature, vol. 538, no. 7624, pp. 201-206. https://doi.org/10.1038/nature18964

APA

Mallick, S., Li, H., Lipson, M., Mathieson, I., Gymrek, M., Racimo, F., Zhao, M., Chennagiri, N., Nordenfelt, S., Tandon, A., Skoglund, P., Lazaridis, I., Sankararaman, S., Fu, Q., Rohland, N., Renaud, G., Erlich, Y., Willems, T., Gallo, C., ... Reich, D. (2016). The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature, 538(7624), 201-206. https://doi.org/10.1038/nature18964

Vancouver

Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F et al. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016;538(7624):201-206. doi: 10.1038/nature18964

Author

Mallick, Swapan ; Li, Heng ; Lipson, Mark et al. / The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. In: Nature. 2016 ; Vol. 538, No. 7624. pp. 201-206.

BibTeX

@article{9508739663e242ab87275a3a39ac4c99,
title = "The Simons Genome Diversity Project: 300 genomes from 142 diverse populations",
abstract = "Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.",
author = "Swapan Mallick and Heng Li and Mark Lipson and Iain Mathieson and Melissa Gymrek and Fernando Racimo and Mengyao Zhao and Niru Chennagiri and Susanne Nordenfelt and Arti Tandon and Pontus Skoglund and Iosif Lazaridis and Sriram Sankararaman and Qiaomei Fu and Nadin Rohland and Gabriel Renaud and Yaniv Erlich and Thomas Willems and Carla Gallo and Spence, {Jeffrey P.} and Song, {Yun S.} and Giovanni Poletti and Francois Balloux and {Van Driem}, George and {De Knijff}, Peter and Romero, {Irene Gallego} and Jha, {Aashish R.} and Behar, {Doron M.} and Bravi, {Claudio M.} and Cristian Capelli and Tor Hervig and Andres Moreno-Estrada and Posukh, {Olga L.} and Elena Balanovska and Oleg Balanovsky and Sena Karachanak-Yankova and Hovhannes Sahakyan and Draga Toncheva and Levon Yepiskoposyan and Chris Tyler-Smith and Yali Xue and Abdullah, {M. Syafiq} and Andres Ruiz-Linares and Beall, {Cynthia M.} and {Di Rienzo}, Anna and Choongwon Jeong and Starikovskaya, {Elena B.} and Ene Metspalu and J{\"u}ri Parik and Richard Villems and Henn, {Brenna M.} and Ugur Hodoglugil and Robert Mahley and Antti Sajantila and George Stamatoyannopoulos and Wee, {Joseph T.S.} and Rita Khusainova and Elza Khusnutdinova and Sergey Litvinov and George Ayodo and David Comas and Hammer, {Michael F.} and Toomas Kivisild and William Klitz and Winkler, {Cheryl A.} and Damian Labuda and Michael Bamshad and Jorde, {Lynn B.} and Tishkoff, {Sarah A.} and Watkins, {W. Scott} and Mait Metspalu and Stanislav Dryomov and Rem Sukernik and Lalji Singh and Kumarasamy Thangaraj and Svante Pa{\"a}bo and Janet Kelso and Nick Patterson and David Reich",
note = "Funding Information: The sequencing was funded by the Simons Foundation (SFARI 280376) and the US National Science Foundation (BCS-1032255). Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited, part of Springer Nature.",
year = "2016",
doi = "10.1038/nature18964",
language = "English",
volume = "538",
pages = "201--206",
journal = "Nature",
issn = "0028-0836",
publisher = "Springer Nature",
number = "7624",

}

RIS

TY - JOUR

T1 - The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

AU - Mallick, Swapan

AU - Li, Heng

AU - Lipson, Mark

AU - Mathieson, Iain

AU - Gymrek, Melissa

AU - Racimo, Fernando

AU - Zhao, Mengyao

AU - Chennagiri, Niru

AU - Nordenfelt, Susanne

AU - Tandon, Arti

AU - Skoglund, Pontus

AU - Lazaridis, Iosif

AU - Sankararaman, Sriram

AU - Fu, Qiaomei

AU - Rohland, Nadin

AU - Renaud, Gabriel

AU - Erlich, Yaniv

AU - Willems, Thomas

AU - Gallo, Carla

AU - Spence, Jeffrey P.

AU - Song, Yun S.

AU - Poletti, Giovanni

AU - Balloux, Francois

AU - Van Driem, George

AU - De Knijff, Peter

AU - Romero, Irene Gallego

AU - Jha, Aashish R.

AU - Behar, Doron M.

AU - Bravi, Claudio M.

AU - Capelli, Cristian

AU - Hervig, Tor

AU - Moreno-Estrada, Andres

AU - Posukh, Olga L.

AU - Balanovska, Elena

AU - Balanovsky, Oleg

AU - Karachanak-Yankova, Sena

AU - Sahakyan, Hovhannes

AU - Toncheva, Draga

AU - Yepiskoposyan, Levon

AU - Tyler-Smith, Chris

AU - Xue, Yali

AU - Abdullah, M. Syafiq

AU - Ruiz-Linares, Andres

AU - Beall, Cynthia M.

AU - Di Rienzo, Anna

AU - Jeong, Choongwon

AU - Starikovskaya, Elena B.

AU - Metspalu, Ene

AU - Parik, Jüri

AU - Villems, Richard

AU - Henn, Brenna M.

AU - Hodoglugil, Ugur

AU - Mahley, Robert

AU - Sajantila, Antti

AU - Stamatoyannopoulos, George

AU - Wee, Joseph T.S.

AU - Khusainova, Rita

AU - Khusnutdinova, Elza

AU - Litvinov, Sergey

AU - Ayodo, George

AU - Comas, David

AU - Hammer, Michael F.

AU - Kivisild, Toomas

AU - Klitz, William

AU - Winkler, Cheryl A.

AU - Labuda, Damian

AU - Bamshad, Michael

AU - Jorde, Lynn B.

AU - Tishkoff, Sarah A.

AU - Watkins, W. Scott

AU - Metspalu, Mait

AU - Dryomov, Stanislav

AU - Sukernik, Rem

AU - Singh, Lalji

AU - Thangaraj, Kumarasamy

AU - Paäbo, Svante

AU - Kelso, Janet

AU - Patterson, Nick

AU - Reich, David

N1 - Funding Information: The sequencing was funded by the Simons Foundation (SFARI 280376) and the US National Science Foundation (BCS-1032255). Publisher Copyright: © 2016 Macmillan Publishers Limited, part of Springer Nature.

PY - 2016

Y1 - 2016

N2 - Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.

AB - Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.

UR - http://www.scopus.com/inward/record.url?scp=84991728057&partnerID=8YFLogxK

U2 - 10.1038/nature18964

DO - 10.1038/nature18964

M3 - Article

C2 - 27654912

AN - SCOPUS:84991728057

VL - 538

SP - 201

EP - 206

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7624

ER -

ID: 34659739