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The role of phosphatidyIinositol-3-kinase in carcinogenesis. / Oskina, N. A.; Shcherbakov, A. M.; Ovchinnikova, L. K. et al.

In: Voprosy Onkologii, Vol. 63, No. 4, 2017, p. 545-556.

Research output: Contribution to journal › Article › peer-review

Harvard

Oskina, NA, Shcherbakov, AM, Ovchinnikova, LK, Filipenko, ML & Kushlinsky, NE 2017, 'The role of phosphatidyIinositol-3-kinase in carcinogenesis', Voprosy Onkologii, vol. 63, no. 4, pp. 545-556.

APA

Oskina, N. A., Shcherbakov, A. M., Ovchinnikova, L. K., Filipenko, M. L., & Kushlinsky, N. E. (2017). The role of phosphatidyIinositol-3-kinase in carcinogenesis. Voprosy Onkologii, 63(4), 545-556.

Vancouver

Oskina NA, Shcherbakov AM, Ovchinnikova LK, Filipenko ML, Kushlinsky NE. The role of phosphatidyIinositol-3-kinase in carcinogenesis. Voprosy Onkologii. 2017;63(4):545-556.

Author

Oskina, N. A. ; Shcherbakov, A. M. ; Ovchinnikova, L. K. et al. / The role of phosphatidyIinositol-3-kinase in carcinogenesis. In: Voprosy Onkologii. 2017 ; Vol. 63, No. 4. pp. 545-556.

BibTeX

@article{6188661195e840b4a8d31259c0a33b3b,
title = "The role of phosphatidyIinositol-3-kinase in carcinogenesis",
abstract = "Currently it is established that cancer is a genetic disease and that somatic mutations are the initiators of the carcinogenic process. The PI3K/AKT/mTOR pathway is an important intracellular signaling pathway regulating the cell growth and metabolic activities. Aberrant activation of the PI3K. pathway is commonly observed in many different cancers. In this review we analyze the genetic alterations of PI3K pathway in a variety of human malignancies and discuss their possible implications for diagnosis and therapy.",
keywords = "5-bisphosphate 3-kinase, Apoptosis, Carcinogenesis, Catalytic subunit alpha (PIK3CA), Phos-phatidylinositol-4, Phosphatidylinositol-3-kinases (PI3K), PI3K/AKT/mTOR pathway",
author = "Oskina, {N. A.} and Shcherbakov, {A. M.} and Ovchinnikova, {L. K.} and Filipenko, {M. L.} and Kushlinsky, {N. E.}",
year = "2017",
language = "English",
volume = "63",
pages = "545--556",
journal = "Voprosy Onkologii",
issn = "0507-3758",
publisher = "Izdatelstvo Meditsina",
number = "4",

}

RIS

TY - JOUR

T1 - The role of phosphatidyIinositol-3-kinase in carcinogenesis

AU - Oskina, N. A.

AU - Shcherbakov, A. M.

AU - Ovchinnikova, L. K.

AU - Filipenko, M. L.

AU - Kushlinsky, N. E.

PY - 2017

Y1 - 2017

N2 - Currently it is established that cancer is a genetic disease and that somatic mutations are the initiators of the carcinogenic process. The PI3K/AKT/mTOR pathway is an important intracellular signaling pathway regulating the cell growth and metabolic activities. Aberrant activation of the PI3K. pathway is commonly observed in many different cancers. In this review we analyze the genetic alterations of PI3K pathway in a variety of human malignancies and discuss their possible implications for diagnosis and therapy.

AB - Currently it is established that cancer is a genetic disease and that somatic mutations are the initiators of the carcinogenic process. The PI3K/AKT/mTOR pathway is an important intracellular signaling pathway regulating the cell growth and metabolic activities. Aberrant activation of the PI3K. pathway is commonly observed in many different cancers. In this review we analyze the genetic alterations of PI3K pathway in a variety of human malignancies and discuss their possible implications for diagnosis and therapy.

KW - 5-bisphosphate 3-kinase

KW - Apoptosis

KW - Carcinogenesis

KW - Catalytic subunit alpha (PIK3CA)

KW - Phos-phatidylinositol-4

KW - Phosphatidylinositol-3-kinases (PI3K)

KW - PI3K/AKT/mTOR pathway

UR - http://www.scopus.com/inward/record.url?scp=85033242650&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85033242650

VL - 63

SP - 545

EP - 556

JO - Voprosy Onkologii

JF - Voprosy Onkologii

SN - 0507-3758

IS - 4

ER -

ID: 9721424