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The role of long non-coding RNAs in the pathogenesis of hereditary diseases. / Sparber, Peter; Filatova, Alexandra; Khantemirova, Mira et al.

In: BMC Medical Genomics, Vol. 12, No. Suppl 2, 42, 13.03.2019, p. 42.

Research output: Contribution to journal › Article › peer-review

Harvard

Sparber, P, Filatova, A, Khantemirova, M & Skoblov, M 2019, 'The role of long non-coding RNAs in the pathogenesis of hereditary diseases', BMC Medical Genomics, vol. 12, no. Suppl 2, 42, pp. 42. https://doi.org/10.1186/s12920-019-0487-6

APA

Sparber, P., Filatova, A., Khantemirova, M., & Skoblov, M. (2019). The role of long non-coding RNAs in the pathogenesis of hereditary diseases. BMC Medical Genomics, 12(Suppl 2), 42. [42]. https://doi.org/10.1186/s12920-019-0487-6

Vancouver

Sparber P, Filatova A, Khantemirova M, Skoblov M. The role of long non-coding RNAs in the pathogenesis of hereditary diseases. BMC Medical Genomics. 2019 Mar 13;12(Suppl 2):42. 42. doi: 10.1186/s12920-019-0487-6

Author

Sparber, Peter ; Filatova, Alexandra ; Khantemirova, Mira et al. / The role of long non-coding RNAs in the pathogenesis of hereditary diseases. In: BMC Medical Genomics. 2019 ; Vol. 12, No. Suppl 2. pp. 42.

BibTeX

@article{364b0067e885403d81d59e12ee6909e1,
title = "The role of long non-coding RNAs in the pathogenesis of hereditary diseases",
abstract = "Background: Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown. Results: This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role. Conclusions: Fundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.",
keywords = "Gene regulation, Hereditary disease, lncRNA, Long non-coding RNA, Medical genetics, METHYLATION, PROTEIN, CIRCULAR RNA, ALZHEIMERS-DISEASE, SINGLE NUCLEOTIDE, H19, MRP RNA, GENE-EXPRESSION, ANTISENSE TRANSCRIPT, LNCRNA",
author = "Peter Sparber and Alexandra Filatova and Mira Khantemirova and Mikhail Skoblov",
year = "2019",
month = mar,
day = "13",
doi = "10.1186/s12920-019-0487-6",
language = "English",
volume = "12",
pages = "42",
journal = "BMC Medical Genomics",
issn = "1755-8794",
publisher = "BioMed Central Ltd.",
number = "Suppl 2",

}

RIS

TY - JOUR

T1 - The role of long non-coding RNAs in the pathogenesis of hereditary diseases

AU - Sparber, Peter

AU - Filatova, Alexandra

AU - Khantemirova, Mira

AU - Skoblov, Mikhail

PY - 2019/3/13

Y1 - 2019/3/13

N2 - Background: Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown. Results: This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role. Conclusions: Fundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.

AB - Background: Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown. Results: This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role. Conclusions: Fundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.

KW - Gene regulation

KW - Hereditary disease

KW - lncRNA

KW - Long non-coding RNA

KW - Medical genetics

KW - METHYLATION

KW - PROTEIN

KW - CIRCULAR RNA

KW - ALZHEIMERS-DISEASE

KW - SINGLE NUCLEOTIDE

KW - H19

KW - MRP RNA

KW - GENE-EXPRESSION

KW - ANTISENSE TRANSCRIPT

KW - LNCRNA

UR - http://www.scopus.com/inward/record.url?scp=85062946632&partnerID=8YFLogxK

U2 - 10.1186/s12920-019-0487-6

DO - 10.1186/s12920-019-0487-6

M3 - Article

C2 - 30871545

AN - SCOPUS:85062946632

VL - 12

SP - 42

JO - BMC Medical Genomics

JF - BMC Medical Genomics

SN - 1755-8794

IS - Suppl 2

M1 - 42

ER -

ID: 18863596