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The role of exosomal tetraspanins and proteases in tumor progression. / Yunusova, N. V.; Tugutova, E. A.; Tamkovich, S. N. et al.

In: Biomeditsinskaya Khimiya, Vol. 64, No. 2, 03.2018, p. 123-133.

Research output: Contribution to journal › Review article › peer-review

Harvard

Yunusova, NV, Tugutova, EA, Tamkovich, SN & Kondakova, IV 2018, 'The role of exosomal tetraspanins and proteases in tumor progression', Biomeditsinskaya Khimiya, vol. 64, no. 2, pp. 123-133. https://doi.org/10.18097/PBMC20186402123

APA

Yunusova, N. V., Tugutova, E. A., Tamkovich, S. N., & Kondakova, I. V. (2018). The role of exosomal tetraspanins and proteases in tumor progression. Biomeditsinskaya Khimiya, 64(2), 123-133. https://doi.org/10.18097/PBMC20186402123

Vancouver

Yunusova NV, Tugutova EA, Tamkovich SN, Kondakova IV. The role of exosomal tetraspanins and proteases in tumor progression. Biomeditsinskaya Khimiya. 2018 Mar;64(2):123-133. doi: 10.18097/PBMC20186402123

Author

Yunusova, N. V. ; Tugutova, E. A. ; Tamkovich, S. N. et al. / The role of exosomal tetraspanins and proteases in tumor progression. In: Biomeditsinskaya Khimiya. 2018 ; Vol. 64, No. 2. pp. 123-133.

BibTeX

@article{b38e0ce71be34c7fa6c24cfe65a938ac,
title = "The role of exosomal tetraspanins and proteases in tumor progression",
abstract = "Major (CD9, CD63, CD81) and others (CD82, CD151, Tspan8) tetraspanins are widely represented in exosomes, where they interact with various proteins and form functional tetraspanin complexes. Tetraspanin complexes include proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in the processes of cell motility, migration, invasion and formation of metastases. Also, a significant contribution to tumor progression is made by proteases that are not associated with tetraspanins. They destabilize intercellular contacts, promote migration and invasion of tumor cells, participate in the regulation of the expression IGF-I, VEGF and transcription factors activation/deactivation. The role of other proteases of exosomes in the processes of tumor progression is being clarified.",
keywords = "Exosomes, Proteases, Tetraspanins, Tumor progression, Cell Movement, Disease Progression, Exosomes, Gene Expression Regulation, Neoplastic, Humans, Neoplasms/enzymology, Peptide Hydrolases/physiology, Tetraspanins/physiology",
author = "Yunusova, {N. V.} and Tugutova, {E. A.} and Tamkovich, {S. N.} and Kondakova, {I. V.}",
year = "2018",
month = mar,
doi = "10.18097/PBMC20186402123",
language = "English",
volume = "64",
pages = "123--133",
journal = "Biomeditsinskaya Khimiya",
issn = "2310-6905",
publisher = "Rossiiskaya Akademiya Meditsinskikh Nauk",
number = "2",

}

RIS

TY - JOUR

T1 - The role of exosomal tetraspanins and proteases in tumor progression

AU - Yunusova, N. V.

AU - Tugutova, E. A.

AU - Tamkovich, S. N.

AU - Kondakova, I. V.

PY - 2018/3

Y1 - 2018/3

N2 - Major (CD9, CD63, CD81) and others (CD82, CD151, Tspan8) tetraspanins are widely represented in exosomes, where they interact with various proteins and form functional tetraspanin complexes. Tetraspanin complexes include proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in the processes of cell motility, migration, invasion and formation of metastases. Also, a significant contribution to tumor progression is made by proteases that are not associated with tetraspanins. They destabilize intercellular contacts, promote migration and invasion of tumor cells, participate in the regulation of the expression IGF-I, VEGF and transcription factors activation/deactivation. The role of other proteases of exosomes in the processes of tumor progression is being clarified.

AB - Major (CD9, CD63, CD81) and others (CD82, CD151, Tspan8) tetraspanins are widely represented in exosomes, where they interact with various proteins and form functional tetraspanin complexes. Tetraspanin complexes include proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in the processes of cell motility, migration, invasion and formation of metastases. Also, a significant contribution to tumor progression is made by proteases that are not associated with tetraspanins. They destabilize intercellular contacts, promote migration and invasion of tumor cells, participate in the regulation of the expression IGF-I, VEGF and transcription factors activation/deactivation. The role of other proteases of exosomes in the processes of tumor progression is being clarified.

KW - Exosomes

KW - Proteases

KW - Tetraspanins

KW - Tumor progression

KW - Cell Movement

KW - Disease Progression

KW - Exosomes

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Neoplasms/enzymology

KW - Peptide Hydrolases/physiology

KW - Tetraspanins/physiology

UR - http://www.scopus.com/inward/record.url?scp=85048130595&partnerID=8YFLogxK

U2 - 10.18097/PBMC20186402123

DO - 10.18097/PBMC20186402123

M3 - Review article

C2 - 29723143

AN - SCOPUS:85048130595

VL - 64

SP - 123

EP - 133

JO - Biomeditsinskaya Khimiya

JF - Biomeditsinskaya Khimiya

SN - 2310-6905

IS - 2

ER -

ID: 13794370