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The Role of Exosomal Tetraspanins and Proteases in Tumor Progression. / Yunusova, N. V.; Tugutova, E. A.; Tamkovich, S. N. et al.

In: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Vol. 12, No. 3, 01.07.2018, p. 191-202.

Research output: Contribution to journal › Article › peer-review

Harvard

Yunusova, NV, Tugutova, EA, Tamkovich, SN & Kondakova, IV 2018, 'The Role of Exosomal Tetraspanins and Proteases in Tumor Progression', Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 12, no. 3, pp. 191-202. https://doi.org/10.1134/S1990750818030095

APA

Yunusova, N. V., Tugutova, E. A., Tamkovich, S. N., & Kondakova, I. V. (2018). The Role of Exosomal Tetraspanins and Proteases in Tumor Progression. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 12(3), 191-202. https://doi.org/10.1134/S1990750818030095

Vancouver

Yunusova NV, Tugutova EA, Tamkovich SN, Kondakova IV. The Role of Exosomal Tetraspanins and Proteases in Tumor Progression. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2018 Jul 1;12(3):191-202. doi: 10.1134/S1990750818030095

Author

Yunusova, N. V. ; Tugutova, E. A. ; Tamkovich, S. N. et al. / The Role of Exosomal Tetraspanins and Proteases in Tumor Progression. In: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2018 ; Vol. 12, No. 3. pp. 191-202.

BibTeX

@article{38e5c7502c714bd4a03356f8ed2cb53b,
title = "The Role of Exosomal Tetraspanins and Proteases in Tumor Progression",
abstract = "Major (CD9, CD63, CD81) and other (CD82, CD151, Tspan8) exosomal tetraspanins interact with various proteins and form functional tetraspanin complexes in exosomes. The tetraspanin complexes contain various proteins including proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in cell motility, migration, invasion and formation of metastases. Proteases that are not associated with tetraspanins also significantly contribute to tumor progression. They destabilize intercellular contacts, promote migration and invasion of tumor cells, and participate in regulation of the expression IGF-I, VEGF, and the activated forms of transcription factors. The role of other exosomal proteases in tumor progression is being clarified.",
keywords = "exosomes, proteases, tetraspanins, tumor progression",
author = "Yunusova, {N. V.} and Tugutova, {E. A.} and Tamkovich, {S. N.} and Kondakova, {I. V.}",
note = "Publisher Copyright: {\textcopyright} 2018, Pleiades Publishing, Ltd.",
year = "2018",
month = jul,
day = "1",
doi = "10.1134/S1990750818030095",
language = "English",
volume = "12",
pages = "191--202",
journal = "Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry",
issn = "1990-7508",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "3",

}

RIS

TY - JOUR

T1 - The Role of Exosomal Tetraspanins and Proteases in Tumor Progression

AU - Yunusova, N. V.

AU - Tugutova, E. A.

AU - Tamkovich, S. N.

AU - Kondakova, I. V.

N1 - Publisher Copyright: © 2018, Pleiades Publishing, Ltd.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Major (CD9, CD63, CD81) and other (CD82, CD151, Tspan8) exosomal tetraspanins interact with various proteins and form functional tetraspanin complexes in exosomes. The tetraspanin complexes contain various proteins including proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in cell motility, migration, invasion and formation of metastases. Proteases that are not associated with tetraspanins also significantly contribute to tumor progression. They destabilize intercellular contacts, promote migration and invasion of tumor cells, and participate in regulation of the expression IGF-I, VEGF, and the activated forms of transcription factors. The role of other exosomal proteases in tumor progression is being clarified.

AB - Major (CD9, CD63, CD81) and other (CD82, CD151, Tspan8) exosomal tetraspanins interact with various proteins and form functional tetraspanin complexes in exosomes. The tetraspanin complexes contain various proteins including proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in cell motility, migration, invasion and formation of metastases. Proteases that are not associated with tetraspanins also significantly contribute to tumor progression. They destabilize intercellular contacts, promote migration and invasion of tumor cells, and participate in regulation of the expression IGF-I, VEGF, and the activated forms of transcription factors. The role of other exosomal proteases in tumor progression is being clarified.

KW - exosomes

KW - proteases

KW - tetraspanins

KW - tumor progression

UR - http://www.scopus.com/inward/record.url?scp=85052247980&partnerID=8YFLogxK

U2 - 10.1134/S1990750818030095

DO - 10.1134/S1990750818030095

M3 - Article

AN - SCOPUS:85052247980

VL - 12

SP - 191

EP - 202

JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

SN - 1990-7508

IS - 3

ER -

ID: 16266176