Research output: Contribution to journal › Article › peer-review
The platelet shape change : biophysical basis and physiological consequences. / Moskalensky, Alexander E.; Litvinenko, Alena L.
In: Platelets, Vol. 30, No. 5, 04.07.2019, p. 543-548.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The platelet shape change
T2 - biophysical basis and physiological consequences
AU - Moskalensky, Alexander E.
AU - Litvinenko, Alena L.
PY - 2019/7/4
Y1 - 2019/7/4
N2 - The well-known platelet shape change is the universal hallmark of activation. This review uncovers the biophysics underlying this rapid and dramatic transformation. We aim to give a broad vision of the interplay between different cytoskeletal subsystems, which is based on physical considerations and recent advances in mathematics and computational biology. These novel findings lead to the understanding that the ring of microtubules counterbalances cortical tension in the resting platelet, making it a “mechanically charged” system. Platelet activation breaks the balance via several mechanisms, triggering rapid ring buckling and cell rounding. Based on the review of known data concerning the relations between platelet shape and function, we hypothesize that disk-to-sphere transformation facilitates platelet adhesion under flow. Conclusions of the paper may be useful for the development of novel, cytoskeletal-based strategies of antiplatelet therapy.
AB - The well-known platelet shape change is the universal hallmark of activation. This review uncovers the biophysics underlying this rapid and dramatic transformation. We aim to give a broad vision of the interplay between different cytoskeletal subsystems, which is based on physical considerations and recent advances in mathematics and computational biology. These novel findings lead to the understanding that the ring of microtubules counterbalances cortical tension in the resting platelet, making it a “mechanically charged” system. Platelet activation breaks the balance via several mechanisms, triggering rapid ring buckling and cell rounding. Based on the review of known data concerning the relations between platelet shape and function, we hypothesize that disk-to-sphere transformation facilitates platelet adhesion under flow. Conclusions of the paper may be useful for the development of novel, cytoskeletal-based strategies of antiplatelet therapy.
KW - Blood platelets
KW - cell shape
KW - cytoskeleton
KW - microtubules
KW - platelet activation
KW - CORTICAL TENSION
KW - CYTOSKELETON
KW - PARTICLES
KW - MICROTUBULES
KW - DEPOLYMERIZATION
KW - MECHANISMS
KW - MARGINAL BAND
KW - DYNAMICS
KW - BINDING
KW - BLOOD-CELLS
UR - http://www.scopus.com/inward/record.url?scp=85065755251&partnerID=8YFLogxK
U2 - 10.1080/09537104.2018.1514109
DO - 10.1080/09537104.2018.1514109
M3 - Article
C2 - 30252574
AN - SCOPUS:85065755251
VL - 30
SP - 543
EP - 548
JO - Platelets
JF - Platelets
SN - 0953-7104
IS - 5
ER -
ID: 20038933