Standard

The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer : A pilot randomized controlled trial. / Efremov, Sergey Mihailovich; Kozireva, Victoria Sergeevna; Moroz, Gleb Borisovich et al.

In: Korean journal of anesthesiology, Vol. 73, No. 6, 12.2020, p. 525-533.

Research output: Contribution to journalArticlepeer-review

Harvard

Efremov, SM, Kozireva, VS, Moroz, GB, Abubakirov, MN, Shkoda, OS, Shilova, AN, Yarmoshuk, SV, Zheravin, AA, Landoni, G & Lomivorotov, VV 2020, 'The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: A pilot randomized controlled trial', Korean journal of anesthesiology, vol. 73, no. 6, pp. 525-533. https://doi.org/10.4097/kja.19461

APA

Efremov, S. M., Kozireva, V. S., Moroz, G. B., Abubakirov, M. N., Shkoda, O. S., Shilova, A. N., Yarmoshuk, S. V., Zheravin, A. A., Landoni, G., & Lomivorotov, V. V. (2020). The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: A pilot randomized controlled trial. Korean journal of anesthesiology, 73(6), 525-533. https://doi.org/10.4097/kja.19461

Vancouver

Efremov SM, Kozireva VS, Moroz GB, Abubakirov MN, Shkoda OS, Shilova AN et al. The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: A pilot randomized controlled trial. Korean journal of anesthesiology. 2020 Dec;73(6):525-533. doi: 10.4097/kja.19461

Author

Efremov, Sergey Mihailovich ; Kozireva, Victoria Sergeevna ; Moroz, Gleb Borisovich et al. / The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer : A pilot randomized controlled trial. In: Korean journal of anesthesiology. 2020 ; Vol. 73, No. 6. pp. 525-533.

BibTeX

@article{ea7490da83f04fd9839e440cbfcf7350,
title = "The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: A pilot randomized controlled trial",
abstract = "Background: The aim of this study was to test the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity compared to total intravenous anesthesia in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia. Methods: Patients were randomly allocated to either propofol-based (intravenous anes-thetic) or sevoflurane-based (volatile anesthetic) anesthesia group with 10 patients in each group, along with epidural analgesia in both groups. Amounts of natural killer (NK) cells, total T lymphocytes, and T lymphocyte subpopulations in the blood samples collected from the patients before surgery, at the end of the surgery and postoperative days 1, 3 and 7 were determined by flow cytometric analysis. The NK cell count served as the primary endpoint of the study, whereas the total T lymphocyte count and cell counts for T lympho-cyte subpopulations were used as the secondary endpoint. Results: Our study showed that there were no significant differences in the amount of NK cells, total T lymphocytes, regulatory T cells, and T-helper cells, cytotoxic T lymphocytes, and their subpopulations between the propofol-and sevoflurane-based anesthesia groups when the anesthesia was administered in combination with epidural analgesia. Conclusions: The results of this pilot study did not support the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity than that of total intravenous anesthesia in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia.",
keywords = "Anesthesia, Cancer, Epidural analgesia, Immunity, Propofol, Sevoflurane",
author = "Efremov, {Sergey Mihailovich} and Kozireva, {Victoria Sergeevna} and Moroz, {Gleb Borisovich} and Abubakirov, {Marat Nikolaevich} and Shkoda, {Olga Sergeevna} and Shilova, {Anna Nikolaevna} and Yarmoshuk, {Sergey Valeriyevich} and Zheravin, {Alexandr Alexandrovich} and Giovanni Landoni and Lomivorotov, {Vladimir Vladimirovich}",
note = "Publisher Copyright: {\textcopyright} The Korean Society of Anesthesiologists, 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.4097/kja.19461",
language = "English",
volume = "73",
pages = "525--533",
journal = "Korean journal of anesthesiology",
issn = "2005-6419",
publisher = "Korean Society of Anesthesiologists",
number = "6",

}

RIS

TY - JOUR

T1 - The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer

T2 - A pilot randomized controlled trial

AU - Efremov, Sergey Mihailovich

AU - Kozireva, Victoria Sergeevna

AU - Moroz, Gleb Borisovich

AU - Abubakirov, Marat Nikolaevich

AU - Shkoda, Olga Sergeevna

AU - Shilova, Anna Nikolaevna

AU - Yarmoshuk, Sergey Valeriyevich

AU - Zheravin, Alexandr Alexandrovich

AU - Landoni, Giovanni

AU - Lomivorotov, Vladimir Vladimirovich

N1 - Publisher Copyright: © The Korean Society of Anesthesiologists, 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Background: The aim of this study was to test the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity compared to total intravenous anesthesia in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia. Methods: Patients were randomly allocated to either propofol-based (intravenous anes-thetic) or sevoflurane-based (volatile anesthetic) anesthesia group with 10 patients in each group, along with epidural analgesia in both groups. Amounts of natural killer (NK) cells, total T lymphocytes, and T lymphocyte subpopulations in the blood samples collected from the patients before surgery, at the end of the surgery and postoperative days 1, 3 and 7 were determined by flow cytometric analysis. The NK cell count served as the primary endpoint of the study, whereas the total T lymphocyte count and cell counts for T lympho-cyte subpopulations were used as the secondary endpoint. Results: Our study showed that there were no significant differences in the amount of NK cells, total T lymphocytes, regulatory T cells, and T-helper cells, cytotoxic T lymphocytes, and their subpopulations between the propofol-and sevoflurane-based anesthesia groups when the anesthesia was administered in combination with epidural analgesia. Conclusions: The results of this pilot study did not support the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity than that of total intravenous anesthesia in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia.

AB - Background: The aim of this study was to test the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity compared to total intravenous anesthesia in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia. Methods: Patients were randomly allocated to either propofol-based (intravenous anes-thetic) or sevoflurane-based (volatile anesthetic) anesthesia group with 10 patients in each group, along with epidural analgesia in both groups. Amounts of natural killer (NK) cells, total T lymphocytes, and T lymphocyte subpopulations in the blood samples collected from the patients before surgery, at the end of the surgery and postoperative days 1, 3 and 7 were determined by flow cytometric analysis. The NK cell count served as the primary endpoint of the study, whereas the total T lymphocyte count and cell counts for T lympho-cyte subpopulations were used as the secondary endpoint. Results: Our study showed that there were no significant differences in the amount of NK cells, total T lymphocytes, regulatory T cells, and T-helper cells, cytotoxic T lymphocytes, and their subpopulations between the propofol-and sevoflurane-based anesthesia groups when the anesthesia was administered in combination with epidural analgesia. Conclusions: The results of this pilot study did not support the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity than that of total intravenous anesthesia in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia.

KW - Anesthesia

KW - Cancer

KW - Epidural analgesia

KW - Immunity

KW - Propofol

KW - Sevoflurane

UR - http://www.scopus.com/inward/record.url?scp=85096951771&partnerID=8YFLogxK

U2 - 10.4097/kja.19461

DO - 10.4097/kja.19461

M3 - Article

C2 - 32098012

AN - SCOPUS:85096951771

VL - 73

SP - 525

EP - 533

JO - Korean journal of anesthesiology

JF - Korean journal of anesthesiology

SN - 2005-6419

IS - 6

ER -

ID: 26167164