The genetic constituent of varicose vein pathogenesis as a key for future treatment option development. / Smetanina, Mariya A.; Shevela, Andrey I.; Gavrilov, Konstantin A. et al.
In: Vessel Plus, Vol. 5, 19, 2021.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - The genetic constituent of varicose vein pathogenesis as a key for future treatment option development
AU - Smetanina, Mariya A.
AU - Shevela, Andrey I.
AU - Gavrilov, Konstantin A.
AU - Filipenko, Maxim L.
N1 - Funding Information: The authors are grateful to the native English speakers Holly Jacob (Texas A&M University, USA) and Christine Tierney (Houston Community College, USA) for grammar checking assistance and thorough text revision. This work was supported by the Program of Fundamental Scientific Research of the Russian Federation (PFSR RF) “Fundamental Basics of Health Preservation” (No. 121031300045-2). Publisher Copyright: © The Author(s) 2021.
PY - 2021
Y1 - 2021
N2 - This perspective focuses primarily on the fundamental part of phlebology, where most attention is paid to the genetic aspects of the pathogenesis of varicose vein disease and where the main breakthrough advances in this area of research are discussed. We propose a direction for further actions to replenish molecular genetic knowledge about the main drivers of pathological processes in varicose vein disease and to complete the creation of an entire picture of pathogenesis, which, in turn, may serve as a key for the development of treatment options in the future in order to translate research evidence into clinical practice.
AB - This perspective focuses primarily on the fundamental part of phlebology, where most attention is paid to the genetic aspects of the pathogenesis of varicose vein disease and where the main breakthrough advances in this area of research are discussed. We propose a direction for further actions to replenish molecular genetic knowledge about the main drivers of pathological processes in varicose vein disease and to complete the creation of an entire picture of pathogenesis, which, in turn, may serve as a key for the development of treatment options in the future in order to translate research evidence into clinical practice.
KW - Epigenetics
KW - Genetics
KW - Pathogenesis
KW - Targets
KW - Varicose veins
UR - http://www.scopus.com/inward/record.url?scp=85114077410&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=47508009
UR - https://www.mendeley.com/catalogue/ff52257a-7d78-3017-9b2a-ec46a5d970ad/
U2 - 10.20517/2574-1209.2021.17
DO - 10.20517/2574-1209.2021.17
M3 - Review article
AN - SCOPUS:85114077410
VL - 5
JO - Vessel Plus
JF - Vessel Plus
SN - 2574-1209
M1 - 19
ER -
ID: 36433519