The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats

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The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats. / Bulygina, V. V.; Men’shanov, P. N.; Lanshakov, D. A. et al.

In: Biology Bulletin, Vol. 41, No. 6, 8, 05.11.2014, p. 540-544.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{dfd30ec1f5a541388f789b0faa099ba4,

title = "The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats",

abstract = "Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.",

author = "Bulygina, {V. V.} and Men{\textquoteright}shanov, {P. N.} and Lanshakov, {D. A.} and Dygalo, {N. N.}",

note = "Funding Information: ACKNOWLEDGMENTS This study was supported by the Russian Founda tion for Basic Research, projects nos. 12 04 01069 a and 14 04 31447 mol_a. Publisher Copyright: {\textcopyright} 2014, Pleiades Publishing, Inc.",

year = "2014",

month = nov,

day = "5",

doi = "10.1134/S1062359014060028",

language = "English",

volume = "41",

pages = "540--544",

journal = "Biology Bulletin",

issn = "1062-3590",

publisher = "PLEIADES PUBLISHING INC",

number = "6",

}

RIS

TY - JOUR

T1 - The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats

AU - Bulygina, V. V.

AU - Men’shanov, P. N.

AU - Lanshakov, D. A.

AU - Dygalo, N. N.

N1 - Funding Information: ACKNOWLEDGMENTS This study was supported by the Russian Founda tion for Basic Research, projects nos. 12 04 01069 a and 14 04 31447 mol_a. Publisher Copyright: © 2014, Pleiades Publishing, Inc.

PY - 2014/11/5

Y1 - 2014/11/5

N2 - Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.

AB - Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.

UR - http://www.scopus.com/inward/record.url?scp=84911484376&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=24006521

U2 - 10.1134/S1062359014060028

DO - 10.1134/S1062359014060028

M3 - Article

AN - SCOPUS:84911484376

VL - 41

SP - 540

EP - 544

JO - Biology Bulletin

JF - Biology Bulletin

SN - 1062-3590

IS - 6

M1 - 8

ER -

ID: 34442318