Research output: Contribution to journal › Article › peer-review
The Effect of Lithium Chloride on the Levels of Brain-Derived Neurotrophic Factor in the Neonatal Brain. / Bannova, A.; Menshanov, P. N.; Dygalo, N. N.
In: Neurochemical Journal, Vol. 13, No. 4, 10.2019, p. 344-348.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The Effect of Lithium Chloride on the Levels of Brain-Derived Neurotrophic Factor in the Neonatal Brain
AU - Bannova, A.
AU - Menshanov, P. N.
AU - Dygalo, N. N.
PY - 2019/10
Y1 - 2019/10
N2 - The brain-derived neurotrophic factor BDNF, which regulates neurogenesis and brain plasticity, mediates the neuroprotective action of the mood stabilizer lithium, which is commonly used in psychiatry. However, it remains unclear whether lithium affects BDNF levels in neonatal brain structures that differ in the maturity levels during ontogeny. Here, we studied the acute effects of lithium chloride (LiCl) treatment on the BDNF levels and levels of the apoptosis marker active caspase-3 in the brainstem and cortex of 3-day-old rats. Lithium increased the BDNF levels in both the brainstem and cortex of rat pups 2 h after injection. In the brainstem, which is more developed at postnatal day 3 in comparison to the cortex, the lithium-induced increase in the BDNF levels was accompanied by a 2-fold decrease in the levels of active caspase-3. These results show that the neuroprotective effects of LiCl treatment in the developing mammalian brain depend on the maturity level of the neonatal brain regions that are affected by the mood stabilizer.
AB - The brain-derived neurotrophic factor BDNF, which regulates neurogenesis and brain plasticity, mediates the neuroprotective action of the mood stabilizer lithium, which is commonly used in psychiatry. However, it remains unclear whether lithium affects BDNF levels in neonatal brain structures that differ in the maturity levels during ontogeny. Here, we studied the acute effects of lithium chloride (LiCl) treatment on the BDNF levels and levels of the apoptosis marker active caspase-3 in the brainstem and cortex of 3-day-old rats. Lithium increased the BDNF levels in both the brainstem and cortex of rat pups 2 h after injection. In the brainstem, which is more developed at postnatal day 3 in comparison to the cortex, the lithium-induced increase in the BDNF levels was accompanied by a 2-fold decrease in the levels of active caspase-3. These results show that the neuroprotective effects of LiCl treatment in the developing mammalian brain depend on the maturity level of the neonatal brain regions that are affected by the mood stabilizer.
KW - brain-derived neurotrophic factor
KW - lithium chloride
KW - developing brain
KW - active caspase-3
KW - MESSENGER-RNA
KW - NERVOUS-SYSTEM
KW - BDNF
KW - RATS
KW - NEUROPROTECTION
KW - EXPRESSION
KW - HIPPOCAMPUS
KW - CASPASE-3
KW - PRECURSOR
KW - NEURONS
U2 - 10.1134/S1819712419030048
DO - 10.1134/S1819712419030048
M3 - Article
VL - 13
SP - 344
EP - 348
JO - Neurochemical Journal
JF - Neurochemical Journal
SN - 1819-7124
IS - 4
ER -
ID: 24302273