The development of Tyrosyl-DNA phosphodiesterase 1 inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

Original language	English
Article number	2767
Journal	Applied Sciences (Switzerland)
Volume	9
Issue number	13
DOIs	https://doi.org/10.3390/app9132767
Publication status	Published - 1 Jul 2019

A-549 lung adenocarcinoma cell line l, Chemical space, Fluorescence biosensor assay, Intrinsic tryptophan fluorescence binding assay, Molecular modelling, Synergy, Thermal shift assay, Topoisomerase 1, Topotecan, synergy, EMPIRICAL SCORING FUNCTIONS, fluorescence biosensor assay, REPAIR, FRAGMENTS, intrinsic tryptophan fluorescence binding assay, CAMPTOTHECIN, BIOLOGICAL EVALUATION, chemical space, DERIVATIVES, topotecan, MECHANISM, molecular modelling, thermal shift assay, PROTEIN-LIGAND DOCKING, TDP1, TOPOISOMERASE-I INHIBITORS

ID: 22321892