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The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome. / Diusenova, Sabina; Arkhipov, Sergey; Avdeev, Dmitry et al.

In: Crystals, Vol. 12, No. 1, 12, 01.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Diusenova, S, Arkhipov, S, Avdeev, D, Dorovatovskii, P, Khachatryan, D, Lazarenko, V, Medvedev, M, Nikolaeva, A, Ovchinnikov, M, Sidorova, M & Zubavichus, Y 2022, 'The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome', Crystals, vol. 12, no. 1, 12. https://doi.org/10.3390/cryst12010012

APA

Diusenova, S., Arkhipov, S., Avdeev, D., Dorovatovskii, P., Khachatryan, D., Lazarenko, V., Medvedev, M., Nikolaeva, A., Ovchinnikov, M., Sidorova, M., & Zubavichus, Y. (2022). The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome. Crystals, 12(1), [12]. https://doi.org/10.3390/cryst12010012

Vancouver

Diusenova S, Arkhipov S, Avdeev D, Dorovatovskii P, Khachatryan D, Lazarenko V et al. The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome. Crystals. 2022 Jan;12(1):12. doi: 10.3390/cryst12010012

Author

Diusenova, Sabina ; Arkhipov, Sergey ; Avdeev, Dmitry et al. / The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome. In: Crystals. 2022 ; Vol. 12, No. 1.

BibTeX

@article{729bf44b78c04d7d89352aa36fd51d8c,
title = "The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome",
abstract = "Herewith, we report for the first time the crystal structure of tetrapeptide FwKT (Phe-D-Trp-Lys-Thr), which is considered to represent an epitope for biomedically relevant hormone somatostatin. The target molecule was successfully crystalized, solved and refined as a conjugate of the tetrapeptide moiety bearing a protective group DOTA at the N-terminus and methylated at the O-terminus. The combination of a hormone active site and a powerful chelator make the substance a highly prospective targeted drug delivery system, especially for peptide receptor radionuclide therapy (PRRT) applications.",
keywords = "Analogue, DOTA, PRRT, Somatostatin, XRD",
author = "Sabina Diusenova and Sergey Arkhipov and Dmitry Avdeev and Pavel Dorovatovskii and Derenik Khachatryan and Vladimir Lazarenko and Michael Medvedev and Alena Nikolaeva and Mikhail Ovchinnikov and Maria Sidorova and Yan Zubavichus",
note = "Funding Information: Funding: This research was partially funded by Russian Ministry of Science and Education via the budget project of SRF SKIF, Boreskov Institute of Catalysis and by the Ministry of Science and Higher Education of the Russian Federation in the implementation of the research program “Use of synchrotron radiation for virologic research” within the framework of the Federal Scientific and Technical Program for the Development of Synchrotron and Neutron Research and Research Infrastructure for 2019–2027 (Agreement No. 075-15-2021-1355 (12 October 2021)). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jan,
doi = "10.3390/cryst12010012",
language = "English",
volume = "12",
journal = "Crystals",
issn = "2073-4352",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

RIS

TY - JOUR

T1 - The crystal structure elucidation of a tetrapeptide analog of somatostatin dota-phe-d-trp-lys-thr-ome

AU - Diusenova, Sabina

AU - Arkhipov, Sergey

AU - Avdeev, Dmitry

AU - Dorovatovskii, Pavel

AU - Khachatryan, Derenik

AU - Lazarenko, Vladimir

AU - Medvedev, Michael

AU - Nikolaeva, Alena

AU - Ovchinnikov, Mikhail

AU - Sidorova, Maria

AU - Zubavichus, Yan

N1 - Funding Information: Funding: This research was partially funded by Russian Ministry of Science and Education via the budget project of SRF SKIF, Boreskov Institute of Catalysis and by the Ministry of Science and Higher Education of the Russian Federation in the implementation of the research program “Use of synchrotron radiation for virologic research” within the framework of the Federal Scientific and Technical Program for the Development of Synchrotron and Neutron Research and Research Infrastructure for 2019–2027 (Agreement No. 075-15-2021-1355 (12 October 2021)). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/1

Y1 - 2022/1

N2 - Herewith, we report for the first time the crystal structure of tetrapeptide FwKT (Phe-D-Trp-Lys-Thr), which is considered to represent an epitope for biomedically relevant hormone somatostatin. The target molecule was successfully crystalized, solved and refined as a conjugate of the tetrapeptide moiety bearing a protective group DOTA at the N-terminus and methylated at the O-terminus. The combination of a hormone active site and a powerful chelator make the substance a highly prospective targeted drug delivery system, especially for peptide receptor radionuclide therapy (PRRT) applications.

AB - Herewith, we report for the first time the crystal structure of tetrapeptide FwKT (Phe-D-Trp-Lys-Thr), which is considered to represent an epitope for biomedically relevant hormone somatostatin. The target molecule was successfully crystalized, solved and refined as a conjugate of the tetrapeptide moiety bearing a protective group DOTA at the N-terminus and methylated at the O-terminus. The combination of a hormone active site and a powerful chelator make the substance a highly prospective targeted drug delivery system, especially for peptide receptor radionuclide therapy (PRRT) applications.

KW - Analogue

KW - DOTA

KW - PRRT

KW - Somatostatin

KW - XRD

UR - http://www.scopus.com/inward/record.url?scp=85121751393&partnerID=8YFLogxK

U2 - 10.3390/cryst12010012

DO - 10.3390/cryst12010012

M3 - Article

AN - SCOPUS:85121751393

VL - 12

JO - Crystals

JF - Crystals

SN - 2073-4352

IS - 1

M1 - 12

ER -

ID: 35175484