Research output: Contribution to journal › Article › peer-review
The bristle pattern development in Drosophila melanogaster : The prepattern and achaete-scute genes. / Furman, D. P.; Bukharina, T. A.
In: Вавиловский журнал генетики и селекции, Vol. 22, No. 8, 01.01.2018, p. 1046-1054.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The bristle pattern development in Drosophila melanogaster
T2 - The prepattern and achaete-scute genes
AU - Furman, D. P.
AU - Bukharina, T. A.
N1 - Publisher Copyright: © AUTHORS, 2018
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The external drosophila mechanoreceptors, residing on the head and body of imago, are represented by bristles of different sizes (macrochaetes and microchaetes). Macrochaetes are arranged in the species-specific bristle pattern, where each of them is strictly positioned. The bristle pattern is formed starting from its prototype (prepattern) in the imaginal disc. The position specificity of future mechanoreceptors is determined by local expression of two proneural genes, achaete (ac) and scute (sc) belonging to the AS-C complex, in response to the action of certain factors, referred to as prepattern factors, nonuniformly distributed in the ectoderm of imaginal discs. The topography of their total distribution defines the bristle prepattern. Thus, the full-fledged adult bristle pattern is the result of interaction of two systems – the prepattern and the system responding to prepattern, i. e., the achaete and scute genes. A considerable volume of miscellaneous experimental data related to various aspects in development of the bristle pattern has been so far accumulated; however, any formalized and detailed representation of the molecular genetic interaction of the prepattern factors with both each other and the achaete-scute genes is yet absent. This review systematizes the available data on the regular patterns of this interaction and shows that local expression of these genes is determined by hierarchical two-level control system comprising both direct and indirect regulators of their activities. A generalized scheme of the system containing the functional interactions of its components is proposed. The structural organization and principles of operation of the hierarchical molecular genetic system enabling the local expression of ASC genes and the resulting formation of ordered bristle pattern are described.
AB - The external drosophila mechanoreceptors, residing on the head and body of imago, are represented by bristles of different sizes (macrochaetes and microchaetes). Macrochaetes are arranged in the species-specific bristle pattern, where each of them is strictly positioned. The bristle pattern is formed starting from its prototype (prepattern) in the imaginal disc. The position specificity of future mechanoreceptors is determined by local expression of two proneural genes, achaete (ac) and scute (sc) belonging to the AS-C complex, in response to the action of certain factors, referred to as prepattern factors, nonuniformly distributed in the ectoderm of imaginal discs. The topography of their total distribution defines the bristle prepattern. Thus, the full-fledged adult bristle pattern is the result of interaction of two systems – the prepattern and the system responding to prepattern, i. e., the achaete and scute genes. A considerable volume of miscellaneous experimental data related to various aspects in development of the bristle pattern has been so far accumulated; however, any formalized and detailed representation of the molecular genetic interaction of the prepattern factors with both each other and the achaete-scute genes is yet absent. This review systematizes the available data on the regular patterns of this interaction and shows that local expression of these genes is determined by hierarchical two-level control system comprising both direct and indirect regulators of their activities. A generalized scheme of the system containing the functional interactions of its components is proposed. The structural organization and principles of operation of the hierarchical molecular genetic system enabling the local expression of ASC genes and the resulting formation of ordered bristle pattern are described.
KW - Achaete-scute gene complex
KW - Bristle pattern
KW - Drosophila melanogaster
KW - Macrochaetes
KW - Prepattern
KW - Proneural cluster
KW - NERVOUS-SYSTEM
KW - PROTEIN
KW - proneural cluster
KW - prepattern
KW - PANNIER
KW - WING IMAGINAL DISC
KW - bristle pattern
KW - SENSORY ORGAN
KW - IROQUOIS COMPLEX
KW - achaete-scute gene complex
KW - GROWTH
KW - macrochaetes
KW - HELIX-LOOP-HELIX
KW - HOMEOBOX GENE
KW - DORSAL MESOTHORAX
UR - http://www.scopus.com/inward/record.url?scp=85064836155&partnerID=8YFLogxK
U2 - 10.18699/VJ18.449
DO - 10.18699/VJ18.449
M3 - Article
AN - SCOPUS:85064836155
VL - 22
SP - 1046
EP - 1054
JO - Вавиловский журнал генетики и селекции
JF - Вавиловский журнал генетики и селекции
SN - 2500-0462
IS - 8
ER -
ID: 19660700