Research output: Contribution to journal › Conference article › peer-review
Terahertz technology in diagnosis of glioma molecular markers. / Kuznetsov, S.; Konnikova, M.; Heinz, T. et al.
In: Journal of Physics: Conference Series, Vol. 2316, No. 1, 012016, 2022.Research output: Contribution to journal › Conference article › peer-review
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TY - JOUR
T1 - Terahertz technology in diagnosis of glioma molecular markers
AU - Kuznetsov, S.
AU - Konnikova, M.
AU - Heinz, T.
AU - Dizer, E.
AU - Nikolaev, N.
AU - Utkin, D.
AU - Cherkasova, O.
N1 - Conference code: 9
PY - 2022
Y1 - 2022
N2 - Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma's differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO2-wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.
AB - Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma's differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO2-wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.
UR - http://www.scopus.com/inward/record.url?scp=85138256372&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/2316/1/012016
DO - 10.1088/1742-6596/2316/1/012016
M3 - Conference article
AN - SCOPUS:85138256372
VL - 2316
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
SN - 1742-6588
IS - 1
M1 - 012016
T2 - 9th International Conference on Modern Nanotechnologies and Nanophotonics for Science and Industry
Y2 - 11 November 2021 through 16 November 2021
ER -
ID: 38035485