TY - JOUR

T1 - Terahertz technology in diagnosis of glioma molecular markers

AU - Kuznetsov, S.

AU - Konnikova, M.

AU - Heinz, T.

AU - Dizer, E.

AU - Nikolaev, N.

AU - Utkin, D.

AU - Cherkasova, O.

N1 - Funding Information: The work was supported by the Russian Foundation for Basic Research RFBR and National Natural Science Foundation of China, research project № 19-52-55004; the Ministry of Science and Higher Education of the Russian Federation within the State assignment FSRC "Crystallography and Photonics" RAS and project № 121032400052-6; the Interdisciplinary Scientific and Educational School of Moscow University “Photonic and Quantum Technologies. Digital Medicine”. Publisher Copyright: © Published under licence by IOP Publishing Ltd.

PY - 2022

Y1 - 2022

N2 - Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma's differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO2-wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.

AB - Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma's differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO2-wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.

UR - http://www.scopus.com/inward/record.url?scp=85138256372&partnerID=8YFLogxK

U2 - 10.1088/1742-6596/2316/1/012016

DO - 10.1088/1742-6596/2316/1/012016

M3 - Conference article

AN - SCOPUS:85138256372

VL - 2316

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

SN - 1742-6588

IS - 1

M1 - 012016

T2 - 9th International Conference on Modern Nanotechnologies and Nanophotonics for Science and Industry, MNNSI-2021

Y2 - 11 November 2021 through 16 November 2021

ER -