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Technique for Generating Dry Aerosol Particles from a Solution : The Case of Fluconazole. / Baklanov, A. M.; Protasov, A. A.; Stekleneva, M. E. et al.

In: Atmospheric and Oceanic Optics, Vol. 37, No. 5, 19.12.2024, p. 715-718.

Research output: Contribution to journal › Article › peer-review

Harvard

Baklanov, AM, Protasov, AA, Stekleneva, ME & Valiulin, SV 2024, 'Technique for Generating Dry Aerosol Particles from a Solution: The Case of Fluconazole', Atmospheric and Oceanic Optics, vol. 37, no. 5, pp. 715-718. https://doi.org/10.1134/S1024856024700957

APA

Baklanov, A. M., Protasov, A. A., Stekleneva, M. E., & Valiulin, S. V. (2024). Technique for Generating Dry Aerosol Particles from a Solution: The Case of Fluconazole. Atmospheric and Oceanic Optics, 37(5), 715-718. https://doi.org/10.1134/S1024856024700957

Vancouver

Baklanov AM, Protasov AA, Stekleneva ME, Valiulin SV. Technique for Generating Dry Aerosol Particles from a Solution: The Case of Fluconazole. Atmospheric and Oceanic Optics. 2024 Dec 19;37(5):715-718. doi: 10.1134/S1024856024700957

Author

Baklanov, A. M. ; Protasov, A. A. ; Stekleneva, M. E. et al. / Technique for Generating Dry Aerosol Particles from a Solution : The Case of Fluconazole. In: Atmospheric and Oceanic Optics. 2024 ; Vol. 37, No. 5. pp. 715-718.

BibTeX

@article{25fa9f47cade4e96963dbd80f8bcd870,
title = "Technique for Generating Dry Aerosol Particles from a Solution: The Case of Fluconazole",
abstract = "Abstract—Infectious diseases affecting the respiratory system are currently a serious medical problem. One of the ways of increasing the effectiveness of therapy for such diseases is targeted delivery of drugs. This approach requires the development of new methods for generating aerosols of drugs with particle sizes which enable penetrating into specified areas of the respiratory system. In this work, a technique for generating dry aerosol particles based on ultrasonic spraying of a drug solution is suggested and implemented. Using the example of a solution of the medicinal antifungal substance fluconazole, we show that this technique enables generating aerosol particles with stable concentration and average size for more than 2 hours. The resulting aerosol has optimal inhalation parameters: size from 1 to 1.9 microns and concentration of 70 000 ± 6500 cm−3. The suggested technique makes it possible to further study the biological effect of aerosols of drugs.",
keywords = "aerosol, aerosol optical spectrometer, fluconazole, inhalation, particle generator, aerosol, aerosol optical spectrometer, fluconazole, inhalation, particle generator",
author = "Baklanov, {A. M.} and Protasov, {A. A.} and Stekleneva, {M. E.} and Valiulin, {S. V.}",
note = "Финансирование: Russian Science Foundation 19-73-10 143",
year = "2024",
month = dec,
day = "19",
doi = "10.1134/S1024856024700957",
language = "English",
volume = "37",
pages = "715--718",
journal = "Atmospheric and Oceanic Optics",
issn = "1024-8560",
publisher = "Springer Science + Business Media",
number = "5",

}

RIS

TY - JOUR

T1 - Technique for Generating Dry Aerosol Particles from a Solution

T2 - The Case of Fluconazole

AU - Baklanov, A. M.

AU - Protasov, A. A.

AU - Stekleneva, M. E.

AU - Valiulin, S. V.

N1 - Финансирование: Russian Science Foundation 19-73-10 143

PY - 2024/12/19

Y1 - 2024/12/19

N2 - Abstract—Infectious diseases affecting the respiratory system are currently a serious medical problem. One of the ways of increasing the effectiveness of therapy for such diseases is targeted delivery of drugs. This approach requires the development of new methods for generating aerosols of drugs with particle sizes which enable penetrating into specified areas of the respiratory system. In this work, a technique for generating dry aerosol particles based on ultrasonic spraying of a drug solution is suggested and implemented. Using the example of a solution of the medicinal antifungal substance fluconazole, we show that this technique enables generating aerosol particles with stable concentration and average size for more than 2 hours. The resulting aerosol has optimal inhalation parameters: size from 1 to 1.9 microns and concentration of 70 000 ± 6500 cm−3. The suggested technique makes it possible to further study the biological effect of aerosols of drugs.

AB - Abstract—Infectious diseases affecting the respiratory system are currently a serious medical problem. One of the ways of increasing the effectiveness of therapy for such diseases is targeted delivery of drugs. This approach requires the development of new methods for generating aerosols of drugs with particle sizes which enable penetrating into specified areas of the respiratory system. In this work, a technique for generating dry aerosol particles based on ultrasonic spraying of a drug solution is suggested and implemented. Using the example of a solution of the medicinal antifungal substance fluconazole, we show that this technique enables generating aerosol particles with stable concentration and average size for more than 2 hours. The resulting aerosol has optimal inhalation parameters: size from 1 to 1.9 microns and concentration of 70 000 ± 6500 cm−3. The suggested technique makes it possible to further study the biological effect of aerosols of drugs.

KW - aerosol

KW - aerosol optical spectrometer

KW - fluconazole

KW - inhalation

KW - particle generator

KW - aerosol

KW - aerosol optical spectrometer

KW - fluconazole

KW - inhalation

KW - particle generator

UR - https://www.mendeley.com/catalogue/073d6871-1992-3b99-8696-47ae8b3bf9a1/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85212706024&origin=inward&txGid=faa3b773c887a52d4739c5fa1b1be425

U2 - 10.1134/S1024856024700957

DO - 10.1134/S1024856024700957

M3 - Article

VL - 37

SP - 715

EP - 718

JO - Atmospheric and Oceanic Optics

JF - Atmospheric and Oceanic Optics

SN - 1024-8560

IS - 5

ER -

ID: 61414538