Research output: Contribution to journal › Article › peer-review
Task-positive and task-negative networks in major depressive disorder: A combined fMRI and EEG study. / Knyazev, Gennady G.; Savostyanov, Alexander N.; Bocharov, Andrey V. et al.
In: Journal of Affective Disorders, Vol. 235, 01.08.2018, p. 211-219.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Task-positive and task-negative networks in major depressive disorder: A combined fMRI and EEG study
AU - Knyazev, Gennady G.
AU - Savostyanov, Alexander N.
AU - Bocharov, Andrey V.
AU - Brak, Ivan V.
AU - Osipov, Evgeny A.
AU - Filimonova, Elena A.
AU - Saprigyn, Alexander E.
AU - Aftanas, Lyubomir I.
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background: The study of intrinsic connectivity networks, i.e., sets of brain regions that show a high degree of interconnectedness even in the absence of a task, showed that major depressive disorder (MDD) patients demonstrate an increased connectivity within the default mode network (DMN), which is active in a resting state and is implicated in self-referential processing, and a decreased connectivity in task-positive networks (TPNs), which increase their activity in attention tasks. Cortical localization of this ‘dominance’ of the DMN over the TPN in MDD patients is not fully understood. Besides, this effect has been investigated using fMRI and its electrophysiological underpinning is not known. Method: In this study, we tested the dominance hypothesis using seed-based connectivity analysis of resting-state fMRI and EEG data obtained in 41 MDD patients and 23 controls. Results: In MDD patients, as compared to controls, insula, pallidum/putamen, amygdala, and left dorso- and ventrolateral prefrontal cortex are more strongly connected with DMN than with TPN seeds. In EEG, all significant effects were obtained in the delta frequency band. Limitations: fMRI and EEG data were not obtained simultaneously during the same session. Conclusions: In MDD patients, major emotion and attention regulation circuits are more strongly connected with DMN than with TPN implying they are more prepared to respond to internally generated self-related thoughts than to environmental challenges.
AB - Background: The study of intrinsic connectivity networks, i.e., sets of brain regions that show a high degree of interconnectedness even in the absence of a task, showed that major depressive disorder (MDD) patients demonstrate an increased connectivity within the default mode network (DMN), which is active in a resting state and is implicated in self-referential processing, and a decreased connectivity in task-positive networks (TPNs), which increase their activity in attention tasks. Cortical localization of this ‘dominance’ of the DMN over the TPN in MDD patients is not fully understood. Besides, this effect has been investigated using fMRI and its electrophysiological underpinning is not known. Method: In this study, we tested the dominance hypothesis using seed-based connectivity analysis of resting-state fMRI and EEG data obtained in 41 MDD patients and 23 controls. Results: In MDD patients, as compared to controls, insula, pallidum/putamen, amygdala, and left dorso- and ventrolateral prefrontal cortex are more strongly connected with DMN than with TPN seeds. In EEG, all significant effects were obtained in the delta frequency band. Limitations: fMRI and EEG data were not obtained simultaneously during the same session. Conclusions: In MDD patients, major emotion and attention regulation circuits are more strongly connected with DMN than with TPN implying they are more prepared to respond to internally generated self-related thoughts than to environmental challenges.
KW - Default mode network
KW - EEG
KW - fMRI
KW - Frontoparietal network
KW - Major depressive disorder
KW - Resting state networks
KW - Salience network
KW - Neural Pathways/physiopathology
KW - Brain Waves/physiology
KW - Humans
KW - Male
KW - Depressive Disorder, Major/physiopathology
KW - Emotions/physiology
KW - Magnetic Resonance Imaging
KW - European Union
KW - Brain Mapping
KW - Adult
KW - Female
UR - http://www.scopus.com/inward/record.url?scp=85045248200&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2018.04.003
DO - 10.1016/j.jad.2018.04.003
M3 - Article
C2 - 29656269
AN - SCOPUS:85045248200
VL - 235
SP - 211
EP - 219
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 12542739