Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline

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Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline. / Ermakova, E. A.; Golubeva, Yu A.; Smirnova, K. S. et al.

In: Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya, Vol. 49, No. 9, 09.2023, p. 593-600.

Research output: Contribution to journal › Article › peer-review

Author

Ermakova, E. A. ; Golubeva, Yu A. ; Smirnova, K. S. et al. / Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline. In: Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya. 2023 ; Vol. 49, No. 9. pp. 593-600.

BibTeX

@article{73ead4fc37be4f02add89de0405146ca,

title = "Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline",

abstract = "The complex [Zn(Phen)(H2O)L2] (I), where HL is 5-benzyltetrazole, Phen is 1,10-phenanthroline, was synthesized. The compound was characterized by standard physicochemical methods (elemental analysis, powder X-ray diffraction, IR spectroscopy). According to X-ray diffraction data (CCDC no. 2220597), zinc coordination environment in the crystal structure of I corresponds to a distorted trigonal bipyramid. The ligand HL is monodentate and is coordinated via tetrazolate ring nitrogen. The stability of complex I was studied by NMR spectroscopy in DMSO. The cytotoxic properties of the compound were assessed against HepG-2 (hepatocellular carcinoma) and MRC-5 (noncancerous human fibroblasts) cells. Complex I exhibits weak cytotoxic properties in the studied concentration range (1–100 µM).",

keywords = "MRC-5, crystal structure, cytotoxicity, zinc",

author = "Ermakova, {E. A.} and Golubeva, {Yu A.} and Smirnova, {K. S.} and Klyushova, {L. S.} and El{\textquoteright}tsov, {I. V.} and Lider, {E. V.}",

note = "This study was supported by the Russian Science Foundation (grant no. 20-73-10207) and the Ministry of Science and Higher Education of the Russian Federation (project no. 121031700321-3). Cytotoxicity assays were carried out using the research equipment of the center for collective use “Proteomic Analysis” of the Federal Research Center for Fundamental and Translational Medicine, supported by the Ministry of Science and Higher Education of the Russian Federation (agreement no. 075-15-2021-691). Публикация для корректировки.",

year = "2023",

month = sep,

doi = "10.1134/S1070328423600158",

language = "English",

volume = "49",

pages = "593--600",

journal = "Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya",

issn = "1070-3284",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "9",

}

RIS

TY - JOUR

T1 - Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline

AU - Ermakova, E. A.

AU - Golubeva, Yu A.

AU - Smirnova, K. S.

AU - Klyushova, L. S.

AU - El’tsov, I. V.

AU - Lider, E. V.

N1 - This study was supported by the Russian Science Foundation (grant no. 20-73-10207) and the Ministry of Science and Higher Education of the Russian Federation (project no. 121031700321-3). Cytotoxicity assays were carried out using the research equipment of the center for collective use “Proteomic Analysis” of the Federal Research Center for Fundamental and Translational Medicine, supported by the Ministry of Science and Higher Education of the Russian Federation (agreement no. 075-15-2021-691). Публикация для корректировки.

PY - 2023/9

Y1 - 2023/9

N2 - The complex [Zn(Phen)(H2O)L2] (I), where HL is 5-benzyltetrazole, Phen is 1,10-phenanthroline, was synthesized. The compound was characterized by standard physicochemical methods (elemental analysis, powder X-ray diffraction, IR spectroscopy). According to X-ray diffraction data (CCDC no. 2220597), zinc coordination environment in the crystal structure of I corresponds to a distorted trigonal bipyramid. The ligand HL is monodentate and is coordinated via tetrazolate ring nitrogen. The stability of complex I was studied by NMR spectroscopy in DMSO. The cytotoxic properties of the compound were assessed against HepG-2 (hepatocellular carcinoma) and MRC-5 (noncancerous human fibroblasts) cells. Complex I exhibits weak cytotoxic properties in the studied concentration range (1–100 µM).

AB - The complex [Zn(Phen)(H2O)L2] (I), where HL is 5-benzyltetrazole, Phen is 1,10-phenanthroline, was synthesized. The compound was characterized by standard physicochemical methods (elemental analysis, powder X-ray diffraction, IR spectroscopy). According to X-ray diffraction data (CCDC no. 2220597), zinc coordination environment in the crystal structure of I corresponds to a distorted trigonal bipyramid. The ligand HL is monodentate and is coordinated via tetrazolate ring nitrogen. The stability of complex I was studied by NMR spectroscopy in DMSO. The cytotoxic properties of the compound were assessed against HepG-2 (hepatocellular carcinoma) and MRC-5 (noncancerous human fibroblasts) cells. Complex I exhibits weak cytotoxic properties in the studied concentration range (1–100 µM).

KW - MRC-5

KW - crystal structure

KW - cytotoxicity

KW - zinc

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85169671888&origin=inward&txGid=6a64bc921b74572b73f283a15924873d

UR - https://www.mendeley.com/catalogue/e5ced3f4-470b-341b-ba83-31bae103c27d/

U2 - 10.1134/S1070328423600158

DO - 10.1134/S1070328423600158

M3 - Article

VL - 49

SP - 593

EP - 600

JO - Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya

JF - Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya

SN - 1070-3284

IS - 9

ER -

ID: 59555799