Synthesis, structure and study of the biological activity of Co(II), Ni(II), and Cu(II) complexes with an enaminedione derivative

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Synthesis, structure and study of the biological activity of Co(II), Ni(II), and Cu(II) complexes with an enaminedione derivative. / Eremina, Yu A.; Ermakova, E. A.; Sukhikh, T. S. et al.

In: Journal of Structural Chemistry, Vol. 62, No. 2, 02.2021, p. 309-320.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{41cb715fcc3f44f7a8b2b8621394291f,

title = "Synthesis, structure and study of the biological activity of Co(II), Ni(II), and Cu(II) complexes with an enaminedione derivative",

abstract = "[Cu(L)2] (1), [Co(L)2] (2), [Ni(L)2]·H2O (3) complexes where L is 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dionate are synthesized. Single crystals of complexes 1-3 are obtained. According to X-ray crystallographic data, in the Co and Ni complexes, a coordination polyhedron N2O4 is a distorted octahedron, and in the Cu complex, N2O2 is a distorted square. L is a tridentate ligand coordinated by oxygen atoms of carbonyl and methoxy groups as well as the nitrogen atom of the amide group. The cytotoxic properties of 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dione and respective complexes are studied on the Hep2 cell line (human laryngeal carcinoma). The compounds are shown to not exhibit cytotoxic properties in the studied concentration range (1-50 μM). Antibacterial, protistocidal, and fungistatic properties of HL, its structural analogue 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL1), and complexes on their base are also studied. The antibacterial activity of HL and [Co(L1)2(C2H5OH)2] against S. aureus, of HL1 and [Co(L)2] against E. coli is revealed within 25-30% of the activity of reference drugs (ciprofloxacin, furazolidone). The [Ni(L1)2(C2H5OH)2] complex is found to have a pronounced protistocidal activity. Furthermore, the behavior of the [Ni(L)2]·H2O complex in phosphate buffered saline is analyzed at storage times t = 0 h, 24 h, 48 h and also in an aqueous solution at different pH values.",

keywords = "antibacterial activity, cobalt, copper, crystal structure, cytotoxicity, enaminedione, mononuclear complexes, nickel",

author = "Eremina, {Yu A.} and Ermakova, {E. A.} and Sukhikh, {T. S.} and Klyushova, {L. S.} and El{\textquoteright}tsov, {I. V.} and Samsonenko, {D. G.} and Dotsenko, {V. V.} and Zubenko, {A. A.} and Fetisov, {L. N.} and Kononenko, {K. N.} and Lider, {E. V.}",

year = "2021",

month = feb,

doi = "10.1134/S0022476621020165",

language = "English",

volume = "62",

pages = "309--320",

journal = "Journal of Structural Chemistry",

issn = "0022-4766",

publisher = "Springer GmbH & Co, Auslieferungs-Gesellschaf",

number = "2",

}

RIS

TY - JOUR

T1 - Synthesis, structure and study of the biological activity of Co(II), Ni(II), and Cu(II) complexes with an enaminedione derivative

AU - Eremina, Yu A.

AU - Ermakova, E. A.

AU - Sukhikh, T. S.

AU - Klyushova, L. S.

AU - El’tsov, I. V.

AU - Samsonenko, D. G.

AU - Dotsenko, V. V.

AU - Zubenko, A. A.

AU - Fetisov, L. N.

AU - Kononenko, K. N.

AU - Lider, E. V.

PY - 2021/2

Y1 - 2021/2

N2 - [Cu(L)2] (1), [Co(L)2] (2), [Ni(L)2]·H2O (3) complexes where L is 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dionate are synthesized. Single crystals of complexes 1-3 are obtained. According to X-ray crystallographic data, in the Co and Ni complexes, a coordination polyhedron N2O4 is a distorted octahedron, and in the Cu complex, N2O2 is a distorted square. L is a tridentate ligand coordinated by oxygen atoms of carbonyl and methoxy groups as well as the nitrogen atom of the amide group. The cytotoxic properties of 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dione and respective complexes are studied on the Hep2 cell line (human laryngeal carcinoma). The compounds are shown to not exhibit cytotoxic properties in the studied concentration range (1-50 μM). Antibacterial, protistocidal, and fungistatic properties of HL, its structural analogue 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL1), and complexes on their base are also studied. The antibacterial activity of HL and [Co(L1)2(C2H5OH)2] against S. aureus, of HL1 and [Co(L)2] against E. coli is revealed within 25-30% of the activity of reference drugs (ciprofloxacin, furazolidone). The [Ni(L1)2(C2H5OH)2] complex is found to have a pronounced protistocidal activity. Furthermore, the behavior of the [Ni(L)2]·H2O complex in phosphate buffered saline is analyzed at storage times t = 0 h, 24 h, 48 h and also in an aqueous solution at different pH values.

AB - [Cu(L)2] (1), [Co(L)2] (2), [Ni(L)2]·H2O (3) complexes where L is 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dionate are synthesized. Single crystals of complexes 1-3 are obtained. According to X-ray crystallographic data, in the Co and Ni complexes, a coordination polyhedron N2O4 is a distorted octahedron, and in the Cu complex, N2O2 is a distorted square. L is a tridentate ligand coordinated by oxygen atoms of carbonyl and methoxy groups as well as the nitrogen atom of the amide group. The cytotoxic properties of 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dione and respective complexes are studied on the Hep2 cell line (human laryngeal carcinoma). The compounds are shown to not exhibit cytotoxic properties in the studied concentration range (1-50 μM). Antibacterial, protistocidal, and fungistatic properties of HL, its structural analogue 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL1), and complexes on their base are also studied. The antibacterial activity of HL and [Co(L1)2(C2H5OH)2] against S. aureus, of HL1 and [Co(L)2] against E. coli is revealed within 25-30% of the activity of reference drugs (ciprofloxacin, furazolidone). The [Ni(L1)2(C2H5OH)2] complex is found to have a pronounced protistocidal activity. Furthermore, the behavior of the [Ni(L)2]·H2O complex in phosphate buffered saline is analyzed at storage times t = 0 h, 24 h, 48 h and also in an aqueous solution at different pH values.

KW - antibacterial activity

KW - cobalt

KW - copper

KW - crystal structure

KW - cytotoxicity

KW - enaminedione

KW - mononuclear complexes

KW - nickel

UR - http://www.scopus.com/inward/record.url?scp=85102718073&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/3a78b076-c307-320a-84a4-945b154f617f/

U2 - 10.1134/S0022476621020165

DO - 10.1134/S0022476621020165

M3 - Article

AN - SCOPUS:85102718073

VL - 62

SP - 309

EP - 320

JO - Journal of Structural Chemistry

JF - Journal of Structural Chemistry

SN - 0022-4766

IS - 2

ER -

ID: 28133147