Standard

Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments. / Cheremnykh, Kirill P.; Savel’ev, Viktor; Shkurko, Oleg P. et al.

In: Chemistry of Heterocyclic Compounds, Vol. 54, No. 12, 18.01.2019, p. 1131-1138.

Research output: Contribution to journal › Article › peer-review

Harvard

Cheremnykh, KP, Savel’ev, V, Shkurko, OP & Shults, EE 2019, 'Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments', Chemistry of Heterocyclic Compounds, vol. 54, no. 12, pp. 1131-1138. https://doi.org/10.1007/s10593-019-02404-w

APA

Cheremnykh, K. P., Savel’ev, V., Shkurko, O. P., & Shults, E. E. (2019). Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments. Chemistry of Heterocyclic Compounds, 54(12), 1131-1138. https://doi.org/10.1007/s10593-019-02404-w

Vancouver

Cheremnykh KP, Savel’ev V, Shkurko OP, Shults EE. Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments. Chemistry of Heterocyclic Compounds. 2019 Jan 18;54(12):1131-1138. doi: 10.1007/s10593-019-02404-w

Author

Cheremnykh, Kirill P. ; Savel’ev, Viktor ; Shkurko, Oleg P. et al. / Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments. In: Chemistry of Heterocyclic Compounds. 2019 ; Vol. 54, No. 12. pp. 1131-1138.

BibTeX

@article{ea34433b60b94ee19c7442f1e88ae021,
title = "Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments",
abstract = "The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.",
keywords = "alkaloids, alkynes, amidines, cross coupling, one-pot synthesis, pyrimidines, DESIGN, ALTAI, FLORA, MODE, BIOLOGICAL EVALUATION, AGENTS, INHIBITORS",
author = "Cheremnykh, {Kirill P.} and Viktor Savel{\textquoteright}ev and Shkurko, {Oleg P.} and Shults, {Elvira E.}",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2019",
month = jan,
day = "18",
doi = "10.1007/s10593-019-02404-w",
language = "English",
volume = "54",
pages = "1131--1138",
journal = "Chemistry of Heterocyclic Compounds",
issn = "0009-3122",
publisher = "Springer New York",
number = "12",

}

RIS

TY - JOUR

T1 - Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments

AU - Cheremnykh, Kirill P.

AU - Savel’ev, Viktor

AU - Shkurko, Oleg P.

AU - Shults, Elvira E.

N1 - Publisher Copyright: © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2019/1/18

Y1 - 2019/1/18

N2 - The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.

AB - The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.

KW - alkaloids

KW - alkynes

KW - amidines

KW - cross coupling

KW - one-pot synthesis

KW - pyrimidines

KW - DESIGN

KW - ALTAI

KW - FLORA

KW - MODE

KW - BIOLOGICAL EVALUATION

KW - AGENTS

KW - INHIBITORS

UR - http://www.scopus.com/inward/record.url?scp=85060186594&partnerID=8YFLogxK

U2 - 10.1007/s10593-019-02404-w

DO - 10.1007/s10593-019-02404-w

M3 - Article

AN - SCOPUS:85060186594

VL - 54

SP - 1131

EP - 1138

JO - Chemistry of Heterocyclic Compounds

JF - Chemistry of Heterocyclic Compounds

SN - 0009-3122

IS - 12

ER -

ID: 18297483