Synthesis of a Novel 9-O Berberine Derivative and Evaluation of Its Hypoglycemic Effect

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Synthesis of a Novel 9-O Berberine Derivative and Evaluation of Its Hypoglycemic Effect. / Gladkova, Elizaveta D.; Valutsa, Nicolae; Borisov, Sergey A. et al.

In: MolBank, Vol. 2023, No. 1, М1597, 03.2023.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{8748eb9437214083b2a37829d2aaffa4,

title = "Synthesis of a Novel 9-O Berberine Derivative and Evaluation of Its Hypoglycemic Effect",

abstract = "Berberine is a phytogenic isoquinoline alkaloid which demonstrates several pharmacological effects, including a hypoglycemic effect. Its medical use is limited by its very low bioavailability. Synthesizing new berberine derivatives might help in overcoming this problem. In this work, we report on the synthesis and biological evaluation of a novel berberine 9-O-derivative. At an oral dose of 25 mg/kg, the compound demonstrated hypoglycemic activity in an oral glucose tolerance test performed using C57BL/6 mice.",

keywords = "OGTT, berberine derivatives, hypoglycemic activity",

author = "Gladkova, {Elizaveta D.} and Nicolae Valutsa and Borisov, {Sergey A.} and Khvostov, {Mikhail V.} and Luzina, {Olga A.} and Tolstikova, {Tatiana G.} and Salakhutdinov, {Nariman F.}",

note = "The work was done within state assignments to N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS (projects No. 1021051402785-4-1.4.1 and No 1021051703312-0-1.4.1). Публикация для корректировки.",

year = "2023",

month = mar,

doi = "10.3390/M1597",

language = "English",

volume = "2023",

journal = "MolBank",

issn = "1422-8599",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

RIS

TY - JOUR

T1 - Synthesis of a Novel 9-O Berberine Derivative and Evaluation of Its Hypoglycemic Effect

AU - Gladkova, Elizaveta D.

AU - Valutsa, Nicolae

AU - Borisov, Sergey A.

AU - Khvostov, Mikhail V.

AU - Luzina, Olga A.

AU - Tolstikova, Tatiana G.

AU - Salakhutdinov, Nariman F.

N1 - The work was done within state assignments to N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS (projects No. 1021051402785-4-1.4.1 and No 1021051703312-0-1.4.1). Публикация для корректировки.

PY - 2023/3

Y1 - 2023/3

N2 - Berberine is a phytogenic isoquinoline alkaloid which demonstrates several pharmacological effects, including a hypoglycemic effect. Its medical use is limited by its very low bioavailability. Synthesizing new berberine derivatives might help in overcoming this problem. In this work, we report on the synthesis and biological evaluation of a novel berberine 9-O-derivative. At an oral dose of 25 mg/kg, the compound demonstrated hypoglycemic activity in an oral glucose tolerance test performed using C57BL/6 mice.

AB - Berberine is a phytogenic isoquinoline alkaloid which demonstrates several pharmacological effects, including a hypoglycemic effect. Its medical use is limited by its very low bioavailability. Synthesizing new berberine derivatives might help in overcoming this problem. In this work, we report on the synthesis and biological evaluation of a novel berberine 9-O-derivative. At an oral dose of 25 mg/kg, the compound demonstrated hypoglycemic activity in an oral glucose tolerance test performed using C57BL/6 mice.

KW - OGTT

KW - berberine derivatives

KW - hypoglycemic activity

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85152389364&origin=inward&txGid=992be96791e2d2cb50bd5dd8ec6b1a99

UR - https://www.mendeley.com/catalogue/63fbc343-50f5-3b83-8543-3d3badcbd0e2/

U2 - 10.3390/M1597

DO - 10.3390/M1597

M3 - Article

VL - 2023

JO - MolBank

JF - MolBank

SN - 1422-8599

IS - 1

M1 - М1597

ER -

ID: 59653683