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Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats. / Tyukova, V. S.; Kedik, S. A.; Panov, A. V. et al.

In: Pharmaceutical Chemistry Journal, Vol. 53, No. 12, 01.03.2020, p. 1158-1163.

Research output: Contribution to journal › Article › peer-review

Harvard

Tyukova, VS, Kedik, SA, Panov, AV, Zhavoronok, ES, Mendeleev, DI, Senchikhin, IN, Fursova, AZ, Rumyantseva, YV & Kolosova, NG 2020, 'Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats', Pharmaceutical Chemistry Journal, vol. 53, no. 12, pp. 1158-1163. https://doi.org/10.1007/s11094-020-02140-y

APA

Tyukova, V. S., Kedik, S. A., Panov, A. V., Zhavoronok, E. S., Mendeleev, D. I., Senchikhin, I. N., Fursova, A. Z., Rumyantseva, Y. V., & Kolosova, N. G. (2020). Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats. Pharmaceutical Chemistry Journal, 53(12), 1158-1163. https://doi.org/10.1007/s11094-020-02140-y

Vancouver

Tyukova VS, Kedik SA, Panov AV, Zhavoronok ES, Mendeleev DI, Senchikhin IN et al. Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats. Pharmaceutical Chemistry Journal. 2020 Mar 1;53(12):1158-1163. doi: 10.1007/s11094-020-02140-y

Author

Tyukova, V. S. ; Kedik, S. A. ; Panov, A. V. et al. / Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats. In: Pharmaceutical Chemistry Journal. 2020 ; Vol. 53, No. 12. pp. 1158-1163.

BibTeX

@article{f4f153adb20c4868b0d46289e7e0f84a,
title = "Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats",
abstract = "Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning calorimetry, and thermogravimetry followed by IR spectroscopy of the evolved gas mixture. Inclusion complexes were prepared in two ways using EtOH or distilled H2O as the solvent. Formation of an inclusion complex increased the thermal stability of disulfiram. Biological studies showed that the disulfiram inclusion complex was effective for preventing cataracts in OXYS rats.",
keywords = "disulfiram, hydroxypropyl-β-cyclodextrin, inclusion complex, physical mixture, solubility, thermal degradation products, thermal stability, hydroxypropyl-beta-cyclodextrin, DIETHYLDITHIOCARBAMATE, DISULFIRAM, EYE DROPS, LENS, PEROXIDE",
author = "Tyukova, {V. S.} and Kedik, {S. A.} and Panov, {A. V.} and Zhavoronok, {E. S.} and Mendeleev, {D. I.} and Senchikhin, {I. N.} and Fursova, {A. Zh} and Rumyantseva, {Yu V.} and Kolosova, {N. G.}",
year = "2020",
month = mar,
day = "1",
doi = "10.1007/s11094-020-02140-y",
language = "English",
volume = "53",
pages = "1158--1163",
journal = "Pharmaceutical Chemistry Journal",
issn = "0091-150X",
publisher = "Springer New York",
number = "12",

}

RIS

TY - JOUR

T1 - Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats

AU - Tyukova, V. S.

AU - Kedik, S. A.

AU - Panov, A. V.

AU - Zhavoronok, E. S.

AU - Mendeleev, D. I.

AU - Senchikhin, I. N.

AU - Fursova, A. Zh

AU - Rumyantseva, Yu V.

AU - Kolosova, N. G.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning calorimetry, and thermogravimetry followed by IR spectroscopy of the evolved gas mixture. Inclusion complexes were prepared in two ways using EtOH or distilled H2O as the solvent. Formation of an inclusion complex increased the thermal stability of disulfiram. Biological studies showed that the disulfiram inclusion complex was effective for preventing cataracts in OXYS rats.

AB - Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning calorimetry, and thermogravimetry followed by IR spectroscopy of the evolved gas mixture. Inclusion complexes were prepared in two ways using EtOH or distilled H2O as the solvent. Formation of an inclusion complex increased the thermal stability of disulfiram. Biological studies showed that the disulfiram inclusion complex was effective for preventing cataracts in OXYS rats.

KW - disulfiram

KW - hydroxypropyl-β-cyclodextrin

KW - inclusion complex

KW - physical mixture

KW - solubility

KW - thermal degradation products

KW - thermal stability

KW - hydroxypropyl-beta-cyclodextrin

KW - DIETHYLDITHIOCARBAMATE

KW - DISULFIRAM

KW - EYE DROPS

KW - LENS

KW - PEROXIDE

UR - http://www.scopus.com/inward/record.url?scp=85081921883&partnerID=8YFLogxK

U2 - 10.1007/s11094-020-02140-y

DO - 10.1007/s11094-020-02140-y

M3 - Article

AN - SCOPUS:85081921883

VL - 53

SP - 1158

EP - 1163

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

SN - 0091-150X

IS - 12

ER -

ID: 23825249