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Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections. / Sokolova, A. S.; Baranova, D. V.; Yarovaya, O. I. et al.

In: Russian Chemical Bulletin, Vol. 68, No. 5, 01.05.2019, p. 1041-1046.

Research output: Contribution to journal › Article › peer-review

Harvard

Sokolova, AS, Baranova, DV, Yarovaya, OI, Baev, DS, Polezhaeva, OA, Zybkina, AV, Shcherbakov, DN, Tolstikova, TG & Salakhutdinov, NF 2019, 'Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections', Russian Chemical Bulletin, vol. 68, no. 5, pp. 1041-1046. https://doi.org/10.1007/s11172-019-2517-0

APA

Sokolova, A. S., Baranova, D. V., Yarovaya, O. I., Baev, D. S., Polezhaeva, O. A., Zybkina, A. V., Shcherbakov, D. N., Tolstikova, T. G., & Salakhutdinov, N. F. (2019). Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections. Russian Chemical Bulletin, 68(5), 1041-1046. https://doi.org/10.1007/s11172-019-2517-0

Vancouver

Sokolova AS, Baranova DV, Yarovaya OI, Baev DS, Polezhaeva OA, Zybkina AV et al. Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections. Russian Chemical Bulletin. 2019 May 1;68(5):1041-1046. doi: 10.1007/s11172-019-2517-0

Author

Sokolova, A. S. ; Baranova, D. V. ; Yarovaya, O. I. et al. / Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections. In: Russian Chemical Bulletin. 2019 ; Vol. 68, No. 5. pp. 1041-1046.

BibTeX

@article{5fd3616ffe094715817e7b5a1b34b820,
title = "Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections",
abstract = "N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.",
keywords = "(1S)-(+)-camphor-10-sulfonic acid, Ebola virus, Marburg virus, molecular docking, N-heterocycles, pseudotyped viruses",
author = "Sokolova, {A. S.} and Baranova, {D. V.} and Yarovaya, {O. I.} and Baev, {D. S.} and Polezhaeva, {O. A.} and Zybkina, {A. V.} and Shcherbakov, {D. N.} and Tolstikova, {T. G.} and Salakhutdinov, {N. F.}",
year = "2019",
month = may,
day = "1",
doi = "10.1007/s11172-019-2517-0",
language = "English",
volume = "68",
pages = "1041--1046",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections

AU - Sokolova, A. S.

AU - Baranova, D. V.

AU - Yarovaya, O. I.

AU - Baev, D. S.

AU - Polezhaeva, O. A.

AU - Zybkina, A. V.

AU - Shcherbakov, D. N.

AU - Tolstikova, T. G.

AU - Salakhutdinov, N. F.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

AB - N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

KW - (1S)-(+)-camphor-10-sulfonic acid

KW - Ebola virus

KW - Marburg virus

KW - molecular docking

KW - N-heterocycles

KW - pseudotyped viruses

UR - http://www.scopus.com/inward/record.url?scp=85067183336&partnerID=8YFLogxK

U2 - 10.1007/s11172-019-2517-0

DO - 10.1007/s11172-019-2517-0

M3 - Article

AN - SCOPUS:85067183336

VL - 68

SP - 1041

EP - 1046

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 5

ER -

ID: 20583548