Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline

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Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline. / Savinykh, P. E.; Golubeva, Y. A.; Smirnova, K. S. et al.

In: Journal of Structural Chemistry, Vol. 65, No. 7, 17, 07.2024, p. 1465-1476.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{371a267c3d8c404e86b387700e712305,

title = "Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline",

abstract = "The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2′-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]n (1), [Cu(phen)(H2O)L2] (2), [Cu(dmphen)(H2O)L2] (3), [Cu(Cl-phen)(H2O)L2] (4), [Cu(bipy)(H2O)L2] (5). According to the XRD data, the phosphinate anion L– exhibits a monodentate coordination in mononuclear complexes 2–5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range.",

keywords = "1,10-phenanthroline, copper(II) complexes, crystal structure, cytotoxicity, di(o-tolyl)phosphinic acid, selectivity index",

author = "Savinykh, {P. E.} and Golubeva, {Y. A.} and Smirnova, {K. S.} and Klyushova, {L. S.} and Davydova, {M. P.} and Artemiev, {A. V.} and Lider, {E. V.}",

note = "This study was funded by the Ministry of Science and Higher Education of the Russian Federation (project No. 121031700321-3). Cytotoxic properties of the considered compounds was studied on the equipment of the Center for Collective Use “Proteomic Analysis” of the Federal Research Center of Fundamental and Translational Medicine and supported by the Ministry of Science and Higher Education of the Russian Federation (project No. 122032200236-1). This work was funded by the Russian Science Foundation (project No. 20-73-10207).",

year = "2024",

month = jul,

doi = "10.1134/S0022476624070175",

language = "English",

volume = "65",

pages = "1465--1476",

journal = "Journal of Structural Chemistry",

issn = "0022-4766",

publisher = "Springer GmbH & Co, Auslieferungs-Gesellschaf",

number = "7",

}

RIS

TY - JOUR

T1 - Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline

AU - Savinykh, P. E.

AU - Golubeva, Y. A.

AU - Smirnova, K. S.

AU - Klyushova, L. S.

AU - Davydova, M. P.

AU - Artemiev, A. V.

AU - Lider, E. V.

N1 - This study was funded by the Ministry of Science and Higher Education of the Russian Federation (project No. 121031700321-3). Cytotoxic properties of the considered compounds was studied on the equipment of the Center for Collective Use “Proteomic Analysis” of the Federal Research Center of Fundamental and Translational Medicine and supported by the Ministry of Science and Higher Education of the Russian Federation (project No. 122032200236-1). This work was funded by the Russian Science Foundation (project No. 20-73-10207).

PY - 2024/7

Y1 - 2024/7

N2 - The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2′-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]n (1), [Cu(phen)(H2O)L2] (2), [Cu(dmphen)(H2O)L2] (3), [Cu(Cl-phen)(H2O)L2] (4), [Cu(bipy)(H2O)L2] (5). According to the XRD data, the phosphinate anion L– exhibits a monodentate coordination in mononuclear complexes 2–5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range.

AB - The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2′-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]n (1), [Cu(phen)(H2O)L2] (2), [Cu(dmphen)(H2O)L2] (3), [Cu(Cl-phen)(H2O)L2] (4), [Cu(bipy)(H2O)L2] (5). According to the XRD data, the phosphinate anion L– exhibits a monodentate coordination in mononuclear complexes 2–5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range.

KW - 1,10-phenanthroline

KW - copper(II) complexes

KW - crystal structure

KW - cytotoxicity

KW - di(o-tolyl)phosphinic acid

KW - selectivity index

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85199767512&origin=inward

UR - https://elibrary.ru/item.asp?id=68538000

UR - https://www.mendeley.com/catalogue/ed6f45bd-571e-3b40-8c51-ee934c1066e1/

U2 - 10.1134/S0022476624070175

DO - 10.1134/S0022476624070175

M3 - Article

VL - 65

SP - 1465

EP - 1476

JO - Journal of Structural Chemistry

JF - Journal of Structural Chemistry

SN - 0022-4766

IS - 7

M1 - 17

ER -

ID: 60512755