Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

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Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). / Zakharenko, A. L.; Mozhaitsev, E. S.; Suslov, E. V. et al.

In: Chemistry of Natural Compounds, Vol. 54, No. 4, 01.07.2018, p. 672-676.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{fa17bc35d02f47fa922299426a263322,

title = "Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)",

abstract = "Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.",

keywords = "adamantane, DNA repair inhibitor, monoterpene, Schiff base, tyrosyl-DNA phosphodiesterase 1, TARGET, CAMPTOTHECIN, BIOLOGICAL EVALUATION, TOP1, IDENTIFICATION, MOIETIES",

author = "Zakharenko, {A. L.} and Mozhaitsev, {E. S.} and Suslov, {E. V.} and Korchagina, {D. V.} and Volcho, {K. P.} and Salakhutdinov, {N. F.} and Lavrik, {O. I.}",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2018",

month = jul,

day = "1",

doi = "10.1007/s10600-018-2443-7",

language = "English",

volume = "54",

pages = "672--676",

journal = "Chemistry of Natural Compounds",

issn = "0009-3130",

publisher = "Springer New York",

number = "4",

}

RIS

TY - JOUR

T1 - Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

AU - Zakharenko, A. L.

AU - Mozhaitsev, E. S.

AU - Suslov, E. V.

AU - Korchagina, D. V.

AU - Volcho, K. P.

AU - Salakhutdinov, N. F.

AU - Lavrik, O. I.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.

AB - Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.

KW - adamantane

KW - DNA repair inhibitor

KW - monoterpene

KW - Schiff base

KW - tyrosyl-DNA phosphodiesterase 1

KW - TARGET

KW - CAMPTOTHECIN

KW - BIOLOGICAL EVALUATION

KW - TOP1

KW - IDENTIFICATION

KW - MOIETIES

UR - http://www.scopus.com/inward/record.url?scp=85050668291&partnerID=8YFLogxK

U2 - 10.1007/s10600-018-2443-7

DO - 10.1007/s10600-018-2443-7

M3 - Article

AN - SCOPUS:85050668291

VL - 54

SP - 672

EP - 676

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 4

ER -

ID: 15945042