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Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides. / Kuranov, S. O.; Blokhin, M. E.; Borisov, S. A. et al.

In: Russian Journal of Bioorganic Chemistry, Vol. 45, No. 5, 01.09.2019, p. 374-380.

Research output: Contribution to journal › Article › peer-review

Harvard

Kuranov, SO, Blokhin, ME, Borisov, SA, Khvostov, MV, Luzina, OA & Salakhutdinov, NF 2019, 'Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides', Russian Journal of Bioorganic Chemistry, vol. 45, no. 5, pp. 374-380. https://doi.org/10.1134/S1068162019050078

APA

Kuranov, S. O., Blokhin, M. E., Borisov, S. A., Khvostov, M. V., Luzina, O. A., & Salakhutdinov, N. F. (2019). Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides. Russian Journal of Bioorganic Chemistry, 45(5), 374-380. https://doi.org/10.1134/S1068162019050078

Vancouver

Kuranov SO, Blokhin ME, Borisov SA, Khvostov MV, Luzina OA, Salakhutdinov NF. Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides. Russian Journal of Bioorganic Chemistry. 2019 Sept 1;45(5):374-380. doi: 10.1134/S1068162019050078

Author

Kuranov, S. O. ; Blokhin, M. E. ; Borisov, S. A. et al. / Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides. In: Russian Journal of Bioorganic Chemistry. 2019 ; Vol. 45, No. 5. pp. 374-380.

BibTeX

@article{cd1aea52a25e472aa0906fab91eca559,
title = "Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides",
abstract = "Abstract: A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.",
keywords = "cyanopyrrolidine, diabetes mellitus type 2, hypoglycemic activity, oral glucose tolerance test, MECHANISM, NATURAL-PRODUCTS, INHIBITORS, DERIVATIVES",
author = "Kuranov, {S. O.} and Blokhin, {M. E.} and Borisov, {S. A.} and Khvostov, {M. V.} and Luzina, {O. A.} and Salakhutdinov, {N. F.}",
note = "Publisher Copyright: {\textcopyright} 2019, Pleiades Publishing, Ltd.",
year = "2019",
month = sep,
day = "1",
doi = "10.1134/S1068162019050078",
language = "English",
volume = "45",
pages = "374--380",
journal = "Russian Journal of Bioorganic Chemistry",
issn = "1068-1620",
publisher = "MAIK NAUKA/INTERPERIODICA/SPRINGER",
number = "5",

}

RIS

TY - JOUR

T1 - Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides

AU - Kuranov, S. O.

AU - Blokhin, M. E.

AU - Borisov, S. A.

AU - Khvostov, M. V.

AU - Luzina, O. A.

AU - Salakhutdinov, N. F.

N1 - Publisher Copyright: © 2019, Pleiades Publishing, Ltd.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Abstract: A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.

AB - Abstract: A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.

KW - cyanopyrrolidine

KW - diabetes mellitus type 2

KW - hypoglycemic activity

KW - oral glucose tolerance test

KW - MECHANISM

KW - NATURAL-PRODUCTS

KW - INHIBITORS

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=85073608016&partnerID=8YFLogxK

U2 - 10.1134/S1068162019050078

DO - 10.1134/S1068162019050078

M3 - Article

AN - SCOPUS:85073608016

VL - 45

SP - 374

EP - 380

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 5

ER -

ID: 21927158