Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4402-4409
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	26
Issue number	15
DOIs	https://doi.org/10.1016/j.bmc.2018.07.018
Publication status	Published - 15 Aug 2018

DIPEPTIDYL-PEPTIDASE-IV, COMPLICATIONS, EPIDEMIOLOGY, DERIVATIVES, INSULIN, DESIGN, POTENT, DRUGS, Alkaloids/chemistry, Dipeptidyl-Peptidase IV Inhibitors/chemical synthesis, Humans, Male, Structure-Activity Relationship, Camphor/chemistry, Pyrrolidines/chemistry, Binding Sites, Catalytic Domain, Glucose Tolerance Test, Dipeptidyl Peptidase 4/chemistry, Hypoglycemic Agents/chemical synthesis, Quinolizines/chemistry, Animals, Diabetes Mellitus, Type 2/drug therapy, Mice, Molecular Docking Simulation, Azocines/chemistry

ID: 15945168