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Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties. / Ponomarev, K. Yu; Morozova, E. A.; Suslov, E. V. et al.

In: Chemistry of Natural Compounds, Vol. 53, No. 6, 01.11.2017, p. 1131-1136.

Research output: Contribution to journal › Article › peer-review

Harvard

Ponomarev, KY, Morozova, EA, Suslov, EV, Korchagina, DV, Tolstikova, TG, Volcho, KP & Salakhutdinov, NF 2017, 'Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties', Chemistry of Natural Compounds, vol. 53, no. 6, pp. 1131-1136. https://doi.org/10.1007/s10600-017-2216-8

APA

Ponomarev, K. Y., Morozova, E. A., Suslov, E. V., Korchagina, D. V., Tolstikova, T. G., Volcho, K. P., & Salakhutdinov, N. F. (2017). Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties. Chemistry of Natural Compounds, 53(6), 1131-1136. https://doi.org/10.1007/s10600-017-2216-8

Vancouver

Ponomarev KY, Morozova EA, Suslov EV, Korchagina DV, Tolstikova TG, Volcho KP et al. Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties. Chemistry of Natural Compounds. 2017 Nov 1;53(6):1131-1136. doi: 10.1007/s10600-017-2216-8

Author

Ponomarev, K. Yu ; Morozova, E. A. ; Suslov, E. V. et al. / Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties. In: Chemistry of Natural Compounds. 2017 ; Vol. 53, No. 6. pp. 1131-1136.

BibTeX

@article{9b73fdd49ce041999bdaf6d6e451ee69,
title = "Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties",
abstract = "A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.",
keywords = "acetate writhing, diazaadamantanes, hot plate, monoterpenes, pain, tertiary amines",
author = "Ponomarev, {K. Yu} and Morozova, {E. A.} and Suslov, {E. V.} and Korchagina, {D. V.} and Tolstikova, {T. G.} and Volcho, {K. P.} and Salakhutdinov, {N. F.}",
note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2017",
month = nov,
day = "1",
doi = "10.1007/s10600-017-2216-8",
language = "English",
volume = "53",
pages = "1131--1136",
journal = "Chemistry of Natural Compounds",
issn = "0009-3130",
publisher = "Springer New York",
number = "6",

}

RIS

TY - JOUR

T1 - Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

AU - Ponomarev, K. Yu

AU - Morozova, E. A.

AU - Suslov, E. V.

AU - Korchagina, D. V.

AU - Tolstikova, T. G.

AU - Volcho, K. P.

AU - Salakhutdinov, N. F.

N1 - Publisher Copyright: © 2017, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

AB - A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

KW - acetate writhing

KW - diazaadamantanes

KW - hot plate

KW - monoterpenes

KW - pain

KW - tertiary amines

UR - http://www.scopus.com/inward/record.url?scp=85034634696&partnerID=8YFLogxK

U2 - 10.1007/s10600-017-2216-8

DO - 10.1007/s10600-017-2216-8

M3 - Article

AN - SCOPUS:85034634696

VL - 53

SP - 1131

EP - 1136

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 6

ER -

ID: 8968960