Substrate specificity of human apurinic/apyrimidinic endonuclease APE1 in the nucleotide incision repair pathway

Adenosine/analogs & derivatives, Catalytic Domain, Cloning, Molecular, DNA Damage, DNA Repair, DNA-(Apurinic or Apyrimidinic Site) Lyase/chemistry, DNA/chemistry, Electron Spin Resonance Spectroscopy, Escherichia coli/genetics, Fluorescence Resonance Energy Transfer, Gene Expression, Humans, Kinetics, Molecular Dynamics Simulation, Nucleic Acid Conformation, Oligodeoxyribonucleotides/chemistry, Protein Binding, Protein Interaction Domains and Motifs, Protein Structure, Secondary, Recombinant Proteins/chemistry, Substrate Specificity, Uridine/analogs & derivatives, ACTIVE-SITE, KINETIC MECHANISM, ABASIC SITE, CONFORMATIONAL DYNAMICS, DAMAGE RECOGNITION, STRUCTURAL-CHANGES, DIVALENT METAL-IONS, BASE-EXCISION, DNA-REPAIR, BINDING

ID: 18488633