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Studying CNS effects of Traditional Chinese Medicine using zebrafish models. / Wang, Dongmei; Hu, Guojun; Wang, Jingtao et al.

In: Journal of Ethnopharmacology, Vol. 267, 113383, 01.03.2021.

Research output: Contribution to journalReview articlepeer-review

Harvard

Wang, D, Hu, G, Wang, J, Yan, D, Wang, M, Yang, LE, Serikuly, N, Alpyshov, E, Demin, KA, Galstyan, DS, Amstislavskaya, TG, de Abreu, MS & Kalueff, AV 2021, 'Studying CNS effects of Traditional Chinese Medicine using zebrafish models', Journal of Ethnopharmacology, vol. 267, 113383. https://doi.org/10.1016/j.jep.2020.113383

APA

Wang, D., Hu, G., Wang, J., Yan, D., Wang, M., Yang, L. E., Serikuly, N., Alpyshov, E., Demin, K. A., Galstyan, D. S., Amstislavskaya, T. G., de Abreu, M. S., & Kalueff, A. V. (2021). Studying CNS effects of Traditional Chinese Medicine using zebrafish models. Journal of Ethnopharmacology, 267, [113383]. https://doi.org/10.1016/j.jep.2020.113383

Vancouver

Wang D, Hu G, Wang J, Yan D, Wang M, Yang LE et al. Studying CNS effects of Traditional Chinese Medicine using zebrafish models. Journal of Ethnopharmacology. 2021 Mar 1;267:113383. Epub 2020 Sept 9. doi: 10.1016/j.jep.2020.113383

Author

Wang, Dongmei ; Hu, Guojun ; Wang, Jingtao et al. / Studying CNS effects of Traditional Chinese Medicine using zebrafish models. In: Journal of Ethnopharmacology. 2021 ; Vol. 267.

BibTeX

@article{f375c44f404f4a8cac8a03c09992ea98,
title = "Studying CNS effects of Traditional Chinese Medicine using zebrafish models",
abstract = "Ethnopharmacological relevance: Although Traditional Chinese Medicine (TCM) has a millennia-long history of treating human brain disorders, its complex multi-target mechanisms of action remain poorly understood. Animal models are currently widely used to probe the effects of various TCMs on brain and behavior. The zebrafish (Danio rerio) has recently emerged as a novel vertebrate model organism for neuroscience research, and is increasingly applied for CNS drug screening and development. Aim of the study: As zebrafish models are only beginning to be applied to studying TCM, we aim to provide a comprehensive review of the TCM effects on brain and behavior in this fish model species. Materials and methods: A comprehensive search of published literature was conducted using biomedical databases (Web of Science, Pubmed, Sciencedirect, Google Scholar and China National Knowledge Internet, CNKI), with key search words zebrafish, brain, Traditional Chinese Medicine, herbs, CNS, behavior. Results: We recognize the developing utility of zebrafish for studying TCM, as well as outline the existing model limitations, problems and challenges, as well as future directions of research in this field. Conclusions: We demonstrate the growing value of zebrafish models for studying TCM, aiming to improve our understanding of TCM{\textquoteright} therapeutic mechanisms and potential in treating brain disorders.",
keywords = "Brain, CNS effects, Drug screening, Traditional Chinese medicine, Zebrafish",
author = "Dongmei Wang and Guojun Hu and Jingtao Wang and Dongni Yan and Mengyao Wang and Yang, {Long En} and Nazar Serikuly and Erik Alpyshov and Demin, {Konstantin A.} and Galstyan, {David S.} and Amstislavskaya, {Tamara G.} and {de Abreu}, {Murilo S.} and Kalueff, {Allan V.}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2021",
month = mar,
day = "1",
doi = "10.1016/j.jep.2020.113383",
language = "English",
volume = "267",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Studying CNS effects of Traditional Chinese Medicine using zebrafish models

AU - Wang, Dongmei

AU - Hu, Guojun

AU - Wang, Jingtao

AU - Yan, Dongni

AU - Wang, Mengyao

AU - Yang, Long En

AU - Serikuly, Nazar

AU - Alpyshov, Erik

AU - Demin, Konstantin A.

AU - Galstyan, David S.

AU - Amstislavskaya, Tamara G.

AU - de Abreu, Murilo S.

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © 2020 Elsevier B.V.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Ethnopharmacological relevance: Although Traditional Chinese Medicine (TCM) has a millennia-long history of treating human brain disorders, its complex multi-target mechanisms of action remain poorly understood. Animal models are currently widely used to probe the effects of various TCMs on brain and behavior. The zebrafish (Danio rerio) has recently emerged as a novel vertebrate model organism for neuroscience research, and is increasingly applied for CNS drug screening and development. Aim of the study: As zebrafish models are only beginning to be applied to studying TCM, we aim to provide a comprehensive review of the TCM effects on brain and behavior in this fish model species. Materials and methods: A comprehensive search of published literature was conducted using biomedical databases (Web of Science, Pubmed, Sciencedirect, Google Scholar and China National Knowledge Internet, CNKI), with key search words zebrafish, brain, Traditional Chinese Medicine, herbs, CNS, behavior. Results: We recognize the developing utility of zebrafish for studying TCM, as well as outline the existing model limitations, problems and challenges, as well as future directions of research in this field. Conclusions: We demonstrate the growing value of zebrafish models for studying TCM, aiming to improve our understanding of TCM’ therapeutic mechanisms and potential in treating brain disorders.

AB - Ethnopharmacological relevance: Although Traditional Chinese Medicine (TCM) has a millennia-long history of treating human brain disorders, its complex multi-target mechanisms of action remain poorly understood. Animal models are currently widely used to probe the effects of various TCMs on brain and behavior. The zebrafish (Danio rerio) has recently emerged as a novel vertebrate model organism for neuroscience research, and is increasingly applied for CNS drug screening and development. Aim of the study: As zebrafish models are only beginning to be applied to studying TCM, we aim to provide a comprehensive review of the TCM effects on brain and behavior in this fish model species. Materials and methods: A comprehensive search of published literature was conducted using biomedical databases (Web of Science, Pubmed, Sciencedirect, Google Scholar and China National Knowledge Internet, CNKI), with key search words zebrafish, brain, Traditional Chinese Medicine, herbs, CNS, behavior. Results: We recognize the developing utility of zebrafish for studying TCM, as well as outline the existing model limitations, problems and challenges, as well as future directions of research in this field. Conclusions: We demonstrate the growing value of zebrafish models for studying TCM, aiming to improve our understanding of TCM’ therapeutic mechanisms and potential in treating brain disorders.

KW - Brain

KW - CNS effects

KW - Drug screening

KW - Traditional Chinese medicine

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85096375626&partnerID=8YFLogxK

U2 - 10.1016/j.jep.2020.113383

DO - 10.1016/j.jep.2020.113383

M3 - Review article

C2 - 32918992

AN - SCOPUS:85096375626

VL - 267

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

M1 - 113383

ER -

ID: 26134549