Research output: Contribution to journal › Article › peer-review
Stress early in life leads to cognitive impairments, reduced numbers of CA3 neurons and altered maternal behavior in adult female mice. / Reshetnikov, Vasiliy V.; Kovner, Anna V.; Lepeshko, Arina A. et al.
In: Genes, Brain and Behavior, Vol. 19, No. 3, e12541, 01.03.2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Stress early in life leads to cognitive impairments, reduced numbers of CA3 neurons and altered maternal behavior in adult female mice
AU - Reshetnikov, Vasiliy V.
AU - Kovner, Anna V.
AU - Lepeshko, Arina A.
AU - Pavlov, Konstantin S.
AU - Grinkevich, Larisa N.
AU - Bondar, Natalya P.
N1 - Publisher Copyright: © 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The hippocampus is a crucial part of the limbic system involved both in cognitive processing and in the regulation of responses to stress. Adverse experiences early in life can disrupt hippocampal development and lead to impairment of the hypothalamic-pituitary-adrenal axis response to subsequent stressors. In our study, two types of early-life stress were used: prolonged separation of pups from their mothers (for 3 hours/day, maternal separation, MS) and brief separation (for 15 minutes/day, handling, HD). In the first part of our study, we found that adult female mice (F0) who had experienced MS showed reduced locomotor activity and impairment of long-term spatial and recognition memory. Analysis of various hippocampal regions showed that MS reduced the number of mature neurons in CA3 of females, which is perhaps a crucial hippocampal region for learning and memory; however, neurogenesis remained unchanged. In the second part, we measured maternal care in female mice with a history of early-life stress (F0) as well as the behavior of their adult offspring (F1). Our results indicated that MS reduced the level of maternal care in adult females (F0) toward their own progeny and caused sex-specific changes in the social behavior of adult offspring (F1). In contrast to MS, HD had no influence on female behavior or hippocampal plasticity. Overall, our results suggest that prolonged MS early in life affects the adult behavior of F0 female mice and hippocampal neuronal plasticity, whereas the mothers' previous experience has effects on the behavior of their F1 offspring through disturbances of mother-infant interactions.
AB - The hippocampus is a crucial part of the limbic system involved both in cognitive processing and in the regulation of responses to stress. Adverse experiences early in life can disrupt hippocampal development and lead to impairment of the hypothalamic-pituitary-adrenal axis response to subsequent stressors. In our study, two types of early-life stress were used: prolonged separation of pups from their mothers (for 3 hours/day, maternal separation, MS) and brief separation (for 15 minutes/day, handling, HD). In the first part of our study, we found that adult female mice (F0) who had experienced MS showed reduced locomotor activity and impairment of long-term spatial and recognition memory. Analysis of various hippocampal regions showed that MS reduced the number of mature neurons in CA3 of females, which is perhaps a crucial hippocampal region for learning and memory; however, neurogenesis remained unchanged. In the second part, we measured maternal care in female mice with a history of early-life stress (F0) as well as the behavior of their adult offspring (F1). Our results indicated that MS reduced the level of maternal care in adult females (F0) toward their own progeny and caused sex-specific changes in the social behavior of adult offspring (F1). In contrast to MS, HD had no influence on female behavior or hippocampal plasticity. Overall, our results suggest that prolonged MS early in life affects the adult behavior of F0 female mice and hippocampal neuronal plasticity, whereas the mothers' previous experience has effects on the behavior of their F1 offspring through disturbances of mother-infant interactions.
KW - cognition
KW - early-life stress
KW - handling
KW - hippocampus
KW - learning
KW - maternal care
KW - maternal separation
KW - memory
KW - neurogenesis
KW - neuronal plasticity
KW - CHILDHOOD MALTREATMENT
KW - SOCIAL STRESS
KW - ELEVATED PLUS-MAZE
KW - SYNAPTIC PLASTICITY
KW - CARE
KW - MEDIAL PREOPTIC AREA
KW - MEMORY
KW - SEPARATION
KW - DENTATE GYRUS
KW - HIPPOCAMPAL NEUROGENESIS
UR - http://www.scopus.com/inward/record.url?scp=85059094524&partnerID=8YFLogxK
U2 - 10.1111/gbb.12541
DO - 10.1111/gbb.12541
M3 - Article
C2 - 30488555
AN - SCOPUS:85059094524
VL - 19
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
SN - 1601-1848
IS - 3
M1 - e12541
ER -
ID: 18186392