Research output: Contribution to journal › Article › peer-review
Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes. / Endutkin, A. V.; Zharkov, D. O.
In: Moscow University Chemistry Bulletin, Vol. 79, No. 2, 7, 04.2024, p. 121-126.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes
AU - Endutkin, A. V.
AU - Zharkov, D. O.
N1 - This study was supported by the Russian Science Foundation (grant no. 21-74-10104) and partly supported by the Ministry of Science and Higher Education of the Russian Federation (project no. 12103130056-8).
PY - 2024/4
Y1 - 2024/4
N2 - DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged nucleotides, initiating the process of base excision DNA repair. There are at least eight structural classes of these enzymes, differing in both their substrate specificity and the mechanism of catalysis. The review examines the mechanisms of human and bacterial DNA glycosylases that protect the genome from the major types of DNA damage.
AB - DNA glycosylases are enzymes that hydrolyze the N-glycosidic bond of damaged nucleotides, initiating the process of base excision DNA repair. There are at least eight structural classes of these enzymes, differing in both their substrate specificity and the mechanism of catalysis. The review examines the mechanisms of human and bacterial DNA glycosylases that protect the genome from the major types of DNA damage.
KW - DNA damage
KW - DNA glycosylases
KW - DNA repair
KW - catalytic mechanism
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85195391391&origin=inward&txGid=7c27c096df86e6e4ca6e28860fb8a577
UR - https://elibrary.ru/item.asp?id=68076551
UR - https://www.mendeley.com/catalogue/3c169f09-7b6b-3b34-a541-e71a848d8fe8/
U2 - 10.3103/S0027131424700044
DO - 10.3103/S0027131424700044
M3 - Article
VL - 79
SP - 121
EP - 126
JO - Moscow University Chemistry Bulletin
JF - Moscow University Chemistry Bulletin
SN - 0027-1314
IS - 2
M1 - 7
ER -
ID: 61083540