Research output: Contribution to journal › Article › peer-review
Stabilization of Octahedral Metal Halide Clusters by Host-Guest Complexation with γ-Cyclodextrin: Toward Nontoxic Luminescent Compounds. / Ivanov, Anton A.; Haouas, Mohamed; Evtushok, Darya V. et al.
In: Inorganic Chemistry, Vol. 61, No. 36, 12.09.2022, p. 14462-14469.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Stabilization of Octahedral Metal Halide Clusters by Host-Guest Complexation with γ-Cyclodextrin: Toward Nontoxic Luminescent Compounds
AU - Ivanov, Anton A.
AU - Haouas, Mohamed
AU - Evtushok, Darya V.
AU - Pozmogova, Tatiana N.
AU - Golubeva, Tatiana S.
AU - Molard, Yann
AU - Cordier, Stéphane
AU - Falaise, Clément
AU - Cadot, Emmanuel
AU - Shestopalov, Michael A.
N1 - Funding Information: The authors gratefully acknowledge financial support from LIA-CNRS CLUSPOM, the grant of the President of the Russian Federation (grant no. MD-123.2022.1.3), and the Ministry of Science and Higher Education of the Russian Federation (no. 121031700321-3). This work was also supported by public grants overseen by (i) University of Versailles Saint Quentin, (ii) CNRS, (iii) Region Île-de-France, (iv) and French National Research Agency (ANR) as part of the “Investissements d’Avenir” program (Labex charmmmat, ANR-11-LBX-0039-grant). Publisher Copyright: © 2022 American Chemical Society. All rights reserved.
PY - 2022/9/12
Y1 - 2022/9/12
N2 - γ-Cyclodextrin (γ-CD) interacts in aqueous solution with octahedral halide clusters Na2[{M6X8}Cl6] (M = Mo, W; X = Br, I) to form robust inclusion supramolecular complexes [{M6X8}Cl6@2γ-CD]2-. Single-crystal X-ray diffraction analyses revealed two conformational organizations within the adduct depending on the nature of the inner halide X within the {M6X8} core. Using 35Cl NMR and UV-vis as complementary techniques, the kinetics of the hydrolysis process were shown to increase with the following order: {W6I8} < {W6Br8} ≈ {Mo6I8} < {Mo6Br8}. The complexation with γ-CD drastically enhances the hydrolytic stability of luminescent [{M6X8}Cl6]2-cluster-based units, which was quantitatively proved by the same techniques. The resulting host-guest complexation provides a protective shell against contact with water and offers promising horizons for octahedral clusters in biology as revealed by the low dark cytotoxicity and cellular uptake.
AB - γ-Cyclodextrin (γ-CD) interacts in aqueous solution with octahedral halide clusters Na2[{M6X8}Cl6] (M = Mo, W; X = Br, I) to form robust inclusion supramolecular complexes [{M6X8}Cl6@2γ-CD]2-. Single-crystal X-ray diffraction analyses revealed two conformational organizations within the adduct depending on the nature of the inner halide X within the {M6X8} core. Using 35Cl NMR and UV-vis as complementary techniques, the kinetics of the hydrolysis process were shown to increase with the following order: {W6I8} < {W6Br8} ≈ {Mo6I8} < {Mo6Br8}. The complexation with γ-CD drastically enhances the hydrolytic stability of luminescent [{M6X8}Cl6]2-cluster-based units, which was quantitatively proved by the same techniques. The resulting host-guest complexation provides a protective shell against contact with water and offers promising horizons for octahedral clusters in biology as revealed by the low dark cytotoxicity and cellular uptake.
KW - Crystallography, X-Ray
KW - Magnetic Resonance Spectroscopy
KW - Molecular Conformation
KW - Water/chemistry
KW - gamma-Cyclodextrins/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85137916959&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/83beafa6-8b1d-3f97-ba58-2270a5c59154/
U2 - 10.1021/acs.inorgchem.2c02468
DO - 10.1021/acs.inorgchem.2c02468
M3 - Article
C2 - 36041168
AN - SCOPUS:85137916959
VL - 61
SP - 14462
EP - 14469
JO - Inorganic Chemistry
JF - Inorganic Chemistry
SN - 0020-1669
IS - 36
ER -
ID: 38037129