Research output: Contribution to journal › Article › peer-review
Spontaneous Resolution and Super-coiling in Xerogels of the Products of Photo-Induced Formose Reaction. / Stovbun, Sergey V.; Zanin, Anatoly M.; Shashkov, Mikhail V. et al.
In: Origins of Life and Evolution of Biospheres, Vol. 49, No. 3, 01.09.2019, p. 187-196.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Spontaneous Resolution and Super-coiling in Xerogels of the Products of Photo-Induced Formose Reaction
AU - Stovbun, Sergey V.
AU - Zanin, Anatoly M.
AU - Shashkov, Mikhail V.
AU - Skoblin, Aleksey A.
AU - Zlenko, Dmitry V.
AU - Tverdislov, Vsevolod A.
AU - Mikhaleva, Marya G.
AU - Taran, Oxana P.
AU - Parmon, Valentin N.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - This work addresses the supramolecular self-organization in the xerogels of formose reaction products. The UV-induced formose reaction was held in over-saturated formaldehyde solutions at 70∘C without a catalyst. The solutions of the obtained carbohydrates were dried on a glass slide, and the obtained xerogels demonstrated a prominent optical activity, while the initial solutions were optically inactive. The xerogels contained highly elongated crystalline elements of a helical structure as well as the isometric ones. Thus xerogel formation was accompanied by a spontaneous resolution of enantiomers and separation of different-shaped supramolecular structures. The thick helices were twisted of thinner ones, while the latter were twisted of elementary structures having a diameter much smaller than 400 nm. Similar structural hierarchy is typical of biological macromolecules (DNA, proteins, and cellulose). Summarizing the obtained results, we proposed a hypothetical mechanism explaining the amplification of the initial enantiomeric excess, as well as chiral and chemical purification of the substances which were essential for the evolution of Life to start.
AB - This work addresses the supramolecular self-organization in the xerogels of formose reaction products. The UV-induced formose reaction was held in over-saturated formaldehyde solutions at 70∘C without a catalyst. The solutions of the obtained carbohydrates were dried on a glass slide, and the obtained xerogels demonstrated a prominent optical activity, while the initial solutions were optically inactive. The xerogels contained highly elongated crystalline elements of a helical structure as well as the isometric ones. Thus xerogel formation was accompanied by a spontaneous resolution of enantiomers and separation of different-shaped supramolecular structures. The thick helices were twisted of thinner ones, while the latter were twisted of elementary structures having a diameter much smaller than 400 nm. Similar structural hierarchy is typical of biological macromolecules (DNA, proteins, and cellulose). Summarizing the obtained results, we proposed a hypothetical mechanism explaining the amplification of the initial enantiomeric excess, as well as chiral and chemical purification of the substances which were essential for the evolution of Life to start.
KW - Formose reaction
KW - Self-assembly
KW - Supercoiling
KW - HOMOCHIRALITY
KW - PREBIOTIC CHEMISTRY
KW - SUGARS
KW - CHROMATOGRAPHY
KW - ORIGIN
KW - EVOLUTION
KW - AMINO-ACIDS
KW - EQUILIBRIUM
KW - CHIRAL-SYMMETRY-BREAKING
KW - SELECTION
UR - http://www.scopus.com/inward/record.url?scp=85074050379&partnerID=8YFLogxK
U2 - 10.1007/s11084-019-09583-8
DO - 10.1007/s11084-019-09583-8
M3 - Article
C2 - 31642022
AN - SCOPUS:85074050379
VL - 49
SP - 187
EP - 196
JO - Origins of Life and Evolution of Biospheres
JF - Origins of Life and Evolution of Biospheres
SN - 0169-6149
IS - 3
ER -
ID: 22035709