TY - JOUR

T1 - Species-specific renal and liver responses during infection with food-borne trematodes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

AU - Zaparina, Oxana G.

AU - Kapushchak, Yaroslav K.

AU - Lishai, Ekaterina A.

AU - Hong, Sung Jong

AU - Sripa, Banchob

AU - Pakharukova, Maria Y.

N1 - This work was supported by the Russian Science Foundation (grant number 24-25-00080 to OGZ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Microscopy was performed at the Microscopy Center of the ICG SB RAS (FWNR-2022-0021).

PY - 2024/12

Y1 - 2024/12

N2 - Three food-borne trematodes—Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis—are closely related epidemiologically important species. Despite the similarity of their life cycles, these liver flukes also have marked differences in the geographical range, helminth biology, and hepatobiliary disorders. O. viverrini and C. sinensis are classified as Group 1 biological carcinogens while O. felineus is not. Direct comparisons of systemic response to the liver fluke infections are unexplored aspects. This study was carried out to identify species-specific liver and kidney responses in the hamster models after the infection with one of the three liver flukes. Liver periductal-fibrosis development was similar between hamsters infected with O. felineus or C. sinensis, whereas biliary intraepithelial neoplasia development was noticed predominantly in O. viverrini–infected ones. Species-specific renal damage was detected, including progression of interstitial fibrosis and IgA deposition in glomeruli of O. felineus–infected hamsters and C. sinensis–infected ones. A strong correlation (R = 0.63; P = 0.0001) was found between periductal fibrosis in the liver and kidney interstitial fibrosis. Future comparative studies are needed to elucidate the development of serious complications during the long term of the infection, as well as under the influence of additional factors, including concomitant infections and the use of dimethylnitrosamine to clarify the mechanisms underlying the liver fluke-associated carcinogenesis. Thus, our findings may stimulate new comparative studies on the pathogenicity.

AB - Three food-borne trematodes—Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis—are closely related epidemiologically important species. Despite the similarity of their life cycles, these liver flukes also have marked differences in the geographical range, helminth biology, and hepatobiliary disorders. O. viverrini and C. sinensis are classified as Group 1 biological carcinogens while O. felineus is not. Direct comparisons of systemic response to the liver fluke infections are unexplored aspects. This study was carried out to identify species-specific liver and kidney responses in the hamster models after the infection with one of the three liver flukes. Liver periductal-fibrosis development was similar between hamsters infected with O. felineus or C. sinensis, whereas biliary intraepithelial neoplasia development was noticed predominantly in O. viverrini–infected ones. Species-specific renal damage was detected, including progression of interstitial fibrosis and IgA deposition in glomeruli of O. felineus–infected hamsters and C. sinensis–infected ones. A strong correlation (R = 0.63; P = 0.0001) was found between periductal fibrosis in the liver and kidney interstitial fibrosis. Future comparative studies are needed to elucidate the development of serious complications during the long term of the infection, as well as under the influence of additional factors, including concomitant infections and the use of dimethylnitrosamine to clarify the mechanisms underlying the liver fluke-associated carcinogenesis. Thus, our findings may stimulate new comparative studies on the pathogenicity.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85211047614&origin=inward&txGid=88d4d149439e5a361bc0d9dc08cf7788

UR - https://www.mendeley.com/catalogue/69c5b24e-13a0-3734-9da7-e4cbeec71b4d/

U2 - 10.1371/journal.pone.0311481

DO - 10.1371/journal.pone.0311481

M3 - Article

C2 - 39637122

VL - 19

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 12 December

M1 - e0311481

ER -