Research output: Contribution to journal › Article › peer-review
Spatial distribution of metabolites in the human lens. / Tamara, Semen O.; Yanshole, Lyudmila V.; Yanshole, Vadim V. et al.
In: Experimental eye research, Vol. 143, 01.02.2016, p. 68-74.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Spatial distribution of metabolites in the human lens
AU - Tamara, Semen O.
AU - Yanshole, Lyudmila V.
AU - Yanshole, Vadim V.
AU - Fursova, Anjella Zh
AU - Stepakov, Denis A.
AU - Novoselov, Vladimir P.
AU - Tsentalovich, Yuri P.
N1 - Funding Information: This work was supported by the Russian Scientific Foundation (project № 14-14-00056 ). VVY acknowledges the financial support of the President of RF (project MK-5367.2015.3 ). Publisher Copyright: © 2015 Elsevier Ltd.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Spatial distribution of 34 metabolites along the optical and equatorial axes of the human lens has been determined. For the majority of metabolites, the homogeneous distribution has been observed. That suggests that the rate of the metabolite transformation in the lens is low due to the general metabolic passivity of the lens fiber cells. However, the redox processes are active in the lens; as a result, some metabolites, including antioxidants, demonstrate the "nucleus-depleted" type of distribution, whereas secondary UV filters show the "nucleus-enriched" type. The metabolite concentrations at the lens poles and equator are similar for all metabolites under study. The concentric pattern of the "nucleus-depleted" and "nucleus-enriched" distributions testifies that the metabolite distribution inside the lens is mostly governed by a passive diffusion, relatively free along the fiber cells and retarded in the radial direction across the cells. No significant difference in the metabolite distribution between the normal and cataractous human lenses was found.
AB - Spatial distribution of 34 metabolites along the optical and equatorial axes of the human lens has been determined. For the majority of metabolites, the homogeneous distribution has been observed. That suggests that the rate of the metabolite transformation in the lens is low due to the general metabolic passivity of the lens fiber cells. However, the redox processes are active in the lens; as a result, some metabolites, including antioxidants, demonstrate the "nucleus-depleted" type of distribution, whereas secondary UV filters show the "nucleus-enriched" type. The metabolite concentrations at the lens poles and equator are similar for all metabolites under study. The concentric pattern of the "nucleus-depleted" and "nucleus-enriched" distributions testifies that the metabolite distribution inside the lens is mostly governed by a passive diffusion, relatively free along the fiber cells and retarded in the radial direction across the cells. No significant difference in the metabolite distribution between the normal and cataractous human lenses was found.
KW - Antioxidants
KW - Cataract
KW - Lens
KW - Metabolites
KW - Spatial distribution
UR - http://www.scopus.com/inward/record.url?scp=84945286935&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=24934641
U2 - 10.1016/j.exer.2015.10.015
DO - 10.1016/j.exer.2015.10.015
M3 - Article
C2 - 26500196
AN - SCOPUS:84945286935
VL - 143
SP - 68
EP - 74
JO - Experimental eye research
JF - Experimental eye research
SN - 0014-4835
ER -
ID: 34441139