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Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy. / Redina, O. E.; Abramova, T. O.; Klimov, L. O. et al.

In: Russian Journal of Genetics, Vol. 53, No. 9, 01.09.2017, p. 972-981.

Research output: Contribution to journal › Article › peer-review

Harvard

Redina, OE, Abramova, TO, Klimov, LO, Ryazanova, MA, Fedoseeva, LA, Smolenskaya, SE, Ershov, NI, Dubinina, AD & Markel, AL 2017, 'Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy', Russian Journal of Genetics, vol. 53, no. 9, pp. 972-981. https://doi.org/10.1134/S1022795417080063

APA

Redina, O. E., Abramova, T. O., Klimov, L. O., Ryazanova, M. A., Fedoseeva, L. A., Smolenskaya, S. E., Ershov, N. I., Dubinina, A. D., & Markel, A. L. (2017). Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy. Russian Journal of Genetics, 53(9), 972-981. https://doi.org/10.1134/S1022795417080063

Vancouver

Redina OE, Abramova TO, Klimov LO, Ryazanova MA, Fedoseeva LA, Smolenskaya SE et al. Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy. Russian Journal of Genetics. 2017 Sept 1;53(9):972-981. doi: 10.1134/S1022795417080063

Author

Redina, O. E. ; Abramova, T. O. ; Klimov, L. O. et al. / Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy. In: Russian Journal of Genetics. 2017 ; Vol. 53, No. 9. pp. 972-981.

BibTeX

@article{29b6369f134546fc941afdeec2253fd3,
title = "Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy",
abstract = "Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key genes involved in the development of the stress-sensitive form of arterial hypertension was conducted. Our studies revealed Ephx2 gene encoding soluble epoxide hydrolase (sEH), whose transcription level was significantly higher in all the examined organs. On the basis of other studies and our previous investigations, we concluded the necessity of further studies of Ephx2 gene and an encoded sEH protein as a potential target for pharmacological treatment of stress-sensitive arterial hypertension.",
keywords = "arterial hypertension, ISIAH rat strain, real-time PCR, RNA-Seq, soluble epoxide hydrolase",
author = "Redina, {O. E.} and Abramova, {T. O.} and Klimov, {L. O.} and Ryazanova, {M. A.} and Fedoseeva, {L. A.} and Smolenskaya, {S. E.} and Ershov, {N. I.} and Dubinina, {A. D.} and Markel, {A. L.}",
note = "Publisher Copyright: {\textcopyright} 2017, Pleiades Publishing, Inc.",
year = "2017",
month = sep,
day = "1",
doi = "10.1134/S1022795417080063",
language = "English",
volume = "53",
pages = "972--981",
journal = "Russian Journal of Genetics",
issn = "1022-7954",
publisher = "PLEIADES PUBLISHING INC",
number = "9",

}

RIS

TY - JOUR

T1 - Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy

AU - Redina, O. E.

AU - Abramova, T. O.

AU - Klimov, L. O.

AU - Ryazanova, M. A.

AU - Fedoseeva, L. A.

AU - Smolenskaya, S. E.

AU - Ershov, N. I.

AU - Dubinina, A. D.

AU - Markel, A. L.

N1 - Publisher Copyright: © 2017, Pleiades Publishing, Inc.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key genes involved in the development of the stress-sensitive form of arterial hypertension was conducted. Our studies revealed Ephx2 gene encoding soluble epoxide hydrolase (sEH), whose transcription level was significantly higher in all the examined organs. On the basis of other studies and our previous investigations, we concluded the necessity of further studies of Ephx2 gene and an encoded sEH protein as a potential target for pharmacological treatment of stress-sensitive arterial hypertension.

AB - Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key genes involved in the development of the stress-sensitive form of arterial hypertension was conducted. Our studies revealed Ephx2 gene encoding soluble epoxide hydrolase (sEH), whose transcription level was significantly higher in all the examined organs. On the basis of other studies and our previous investigations, we concluded the necessity of further studies of Ephx2 gene and an encoded sEH protein as a potential target for pharmacological treatment of stress-sensitive arterial hypertension.

KW - arterial hypertension

KW - ISIAH rat strain

KW - real-time PCR

KW - RNA-Seq

KW - soluble epoxide hydrolase

UR - http://www.scopus.com/inward/record.url?scp=85029808948&partnerID=8YFLogxK

U2 - 10.1134/S1022795417080063

DO - 10.1134/S1022795417080063

M3 - Article

AN - SCOPUS:85029808948

VL - 53

SP - 972

EP - 981

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 9

ER -

ID: 8674884