Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex

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Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex : An impact of early-life stress. / Reshetnikov, V. V.; Kisaretova, P. E.; Ershov, N. I. et al.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 106, 110068, 02.03.2021.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{cc4d254e642d4566bf253f2b290502a2,

title = "Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: An impact of early-life stress",

abstract = "Chronic stress is the leading risk factor of a broad range of severe psychopathologies. Nonetheless, the molecular mechanisms triggering these pathological processes are not well understood. In our study, we investigated the effects of 15-day social defeat stress (SDS) on the genome-wide landscape of trimethylation at the 4th lysine residue of histone H3 (H3K4me3) and on the transcriptome in the prefrontal cortex of mice that were reared normally (group SDS) or subjected to maternal separation early in life (group MS+SDS). The mice with the history of stress early in life showed increased susceptibility to SDS in adulthood and demonstrated long-lasting genome-wide alterations in gene expression and splicing as well as in the H3K4me3 epigenetic landscape in the prefrontal cortex. Thus, the high-throughput techniques applied here allowed us to simultaneously detect, for the first time, genome-wide epigenetic and transcriptional changes in the murine prefrontal cortex that are associated with both chronic SDS and increased susceptibility to this stressor.",

keywords = "Alternative splicing, Early-life stress, H3K4me3, RNA-seq, Social defeat stress, CHILDHOOD MALTREATMENT, DEPRESSION, MATRIX GLA PROTEIN, RESILIENCE, TRANSCRIPTION, DISTINCT, MECHANISMS, NUCLEUS-ACCUMBENS, MOLECULAR ADAPTATIONS, PSYCHIATRIC-DISORDERS",

author = "Reshetnikov, {V. V.} and Kisaretova, {P. E.} and Ershov, {N. I.} and Merkulova, {T. I.} and Bondar, {N. P.}",

year = "2021",

month = mar,

day = "2",

doi = "10.1016/j.pnpbp.2020.110068",

language = "English",

volume = "106",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex

T2 - An impact of early-life stress

AU - Reshetnikov, V. V.

AU - Kisaretova, P. E.

AU - Ershov, N. I.

AU - Merkulova, T. I.

AU - Bondar, N. P.

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Chronic stress is the leading risk factor of a broad range of severe psychopathologies. Nonetheless, the molecular mechanisms triggering these pathological processes are not well understood. In our study, we investigated the effects of 15-day social defeat stress (SDS) on the genome-wide landscape of trimethylation at the 4th lysine residue of histone H3 (H3K4me3) and on the transcriptome in the prefrontal cortex of mice that were reared normally (group SDS) or subjected to maternal separation early in life (group MS+SDS). The mice with the history of stress early in life showed increased susceptibility to SDS in adulthood and demonstrated long-lasting genome-wide alterations in gene expression and splicing as well as in the H3K4me3 epigenetic landscape in the prefrontal cortex. Thus, the high-throughput techniques applied here allowed us to simultaneously detect, for the first time, genome-wide epigenetic and transcriptional changes in the murine prefrontal cortex that are associated with both chronic SDS and increased susceptibility to this stressor.

AB - Chronic stress is the leading risk factor of a broad range of severe psychopathologies. Nonetheless, the molecular mechanisms triggering these pathological processes are not well understood. In our study, we investigated the effects of 15-day social defeat stress (SDS) on the genome-wide landscape of trimethylation at the 4th lysine residue of histone H3 (H3K4me3) and on the transcriptome in the prefrontal cortex of mice that were reared normally (group SDS) or subjected to maternal separation early in life (group MS+SDS). The mice with the history of stress early in life showed increased susceptibility to SDS in adulthood and demonstrated long-lasting genome-wide alterations in gene expression and splicing as well as in the H3K4me3 epigenetic landscape in the prefrontal cortex. Thus, the high-throughput techniques applied here allowed us to simultaneously detect, for the first time, genome-wide epigenetic and transcriptional changes in the murine prefrontal cortex that are associated with both chronic SDS and increased susceptibility to this stressor.

KW - Alternative splicing

KW - Early-life stress

KW - H3K4me3

KW - RNA-seq

KW - Social defeat stress

KW - CHILDHOOD MALTREATMENT

KW - DEPRESSION

KW - MATRIX GLA PROTEIN

KW - RESILIENCE

KW - TRANSCRIPTION

KW - DISTINCT

KW - MECHANISMS

KW - NUCLEUS-ACCUMBENS

KW - MOLECULAR ADAPTATIONS

KW - PSYCHIATRIC-DISORDERS

UR - http://www.scopus.com/inward/record.url?scp=85089750722&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2020.110068

DO - 10.1016/j.pnpbp.2020.110068

M3 - Article

C2 - 32810572

AN - SCOPUS:85089750722

VL - 106

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

M1 - 110068

ER -

ID: 25296932

Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: An impact of early-life stress

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