TY - JOUR

T1 - Silver micro- and nanoparticles filled silicone for limb prosthetics

AU - Экшарова, София Алексеевна

AU - Poletaeva, Yuliya E.

AU - Куренкова, Анна Юрьевна

AU - Мищенко, Денис Давыдович

AU - Айдаков, Егор Евгеньевич

AU - Сердюков, Владимир Сергеевич

N1 - The study was supported by the Mathematical Center in Akademgorodok (No. 075-15-2022-282) with the Ministry of Science and Higher Education of the Russian Federation. The X-ray photoelectron spectroscopy and X-ray diffraction studies were performed using the facilities of the shared research center “National Center of Investigation of Catalysts” at Boreskov Institute of Catalysis.

PY - 2025/4/24

Y1 - 2025/4/24

N2 - The threat of bacterial growth on the skin under the prosthetic liners or sleeves is an important problem, which can cause various serious diseases up to the repeated amputation. One of the promising ways to solve this problem is to use antibacterial materials as a liner/ sleeve material. Among others composite based on the silicone polymer with silver particles additive is may be a simple and effective solution, since the silicone is the main material for the prosthetic liners and sleeves and silver demonstrates pronounced antibacterial effect. However, the questions related to the optimal concentration of silver in silicone that results in maximum antibacterial efficiency without harming human skin are still open. In the present work, synthesis of metallic silver powder from a mixture of micro- and nanoparticles was performed and composite samples based on silicone polymer with different silver concentrations were fabricated. The antibacterial properties of fabricated samples were studied using the microdilution method against gram-positive spore-forming bacteria Bacillus subtilis. The cytotoxic effect of the tested samples was evaluated on healthy human fibroblast cell (NAF1nor). Moreover, the effect of adding silver micro- and nanoparticles to silicone on its extensibility and hardness was studied. The results showed that the addition of silver has a noticeable effect on the antibacterial properties of silicone polymer reaching more than 50%. Furthermore, all tested silicone-silver composites were shown to be non-toxic. The presence of silver does not significantly affect the relative elongation of the samples. However, hardness increases with higher silver concentrations. In the final phase, prototypes of the silver-filled silicone prosthetic sleeve were fabricated for utilisation by the patient at the prosthetic-orthopaedic clinic. The testing of the prototype was successfully completed by the patient, thereby demonstrating practical functionality and suitability for clinical use.

AB - The threat of bacterial growth on the skin under the prosthetic liners or sleeves is an important problem, which can cause various serious diseases up to the repeated amputation. One of the promising ways to solve this problem is to use antibacterial materials as a liner/ sleeve material. Among others composite based on the silicone polymer with silver particles additive is may be a simple and effective solution, since the silicone is the main material for the prosthetic liners and sleeves and silver demonstrates pronounced antibacterial effect. However, the questions related to the optimal concentration of silver in silicone that results in maximum antibacterial efficiency without harming human skin are still open. In the present work, synthesis of metallic silver powder from a mixture of micro- and nanoparticles was performed and composite samples based on silicone polymer with different silver concentrations were fabricated. The antibacterial properties of fabricated samples were studied using the microdilution method against gram-positive spore-forming bacteria Bacillus subtilis. The cytotoxic effect of the tested samples was evaluated on healthy human fibroblast cell (NAF1nor). Moreover, the effect of adding silver micro- and nanoparticles to silicone on its extensibility and hardness was studied. The results showed that the addition of silver has a noticeable effect on the antibacterial properties of silicone polymer reaching more than 50%. Furthermore, all tested silicone-silver composites were shown to be non-toxic. The presence of silver does not significantly affect the relative elongation of the samples. However, hardness increases with higher silver concentrations. In the final phase, prototypes of the silver-filled silicone prosthetic sleeve were fabricated for utilisation by the patient at the prosthetic-orthopaedic clinic. The testing of the prototype was successfully completed by the patient, thereby demonstrating practical functionality and suitability for clinical use.

KW - Antibacterial materials

KW - Limb prosthetics

KW - Medical materials

KW - Nanomaterials

KW - Silicone

KW - Silver

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105010964978&origin=inward

U2 - 10.12336/bmt.24.00073

DO - 10.12336/bmt.24.00073

M3 - Article

C2 - 40641990

SP - 202

EP - 211

JO - Biomaterials Translational

JF - Biomaterials Translational

SN - 2096-112X

ER -