Research output: Contribution to journal › Article › peer-review
Siberian genetic diversity reveals complex origins of the Samoyedic-speaking populations. / Karafet, Tatiana M.; Osipova, Ludmila P.; Savina, Olga V. et al.
In: American Journal of Human Biology, Vol. 30, No. 6, 23194, 01.11.2018.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Siberian genetic diversity reveals complex origins of the Samoyedic-speaking populations
AU - Karafet, Tatiana M.
AU - Osipova, Ludmila P.
AU - Savina, Olga V.
AU - Hallmark, Brian
AU - Hammer, Michael F.
N1 - Publisher Copyright: © 2018 Wiley Periodicals, Inc.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Objectives: We examined autosomal genome-wide SNPs and Y-chromosome data from 15 Siberian and 12 reference populations to study the affinities of Siberian populations, and to address hypotheses about the origin of the Samoyed peoples. Methods: Samples were genotyped for 567 096 autosomal SNPs and 147 Y-chromosome polymorphic sites. For several analyses, we used 281 093 SNPs from the intersection of our data with publicly available ancient Siberian samples. To examine genetic relatedness among populations, we applied PCA, FST, TreeMix, and ADMIXTURE analyses. To explore the potential effect of demography and evolutionary processes, the distribution of ROH and IBD sharing within population were studied. Results: Analyses of autosomal and Y-chromosome data reveal high differentiation of the Siberian groups. The Siberian populations have a large proportion of their genome in ROH and IBD segments. Several populations (ie, Nganasans, Evenks, Yukagirs, and Koryaks) do not appear to have experienced admixture with other Siberian populations (ie, producing only positive f3), while for the other tested populations the composition of mixing sources always included Nganasans or Evenks. The Nganasans from the Taymyr Peninsula demonstrate the greatest level of shared shorter ROH and IBD with nearly all other Siberian populations. Conclusions: Autosomal SNP and Y-chromosome data demonstrate that Samoyedic populations differ significantly in their genetic composition. Genetic relationship is observed only between Forest and Tundra Nentsi. Selkups are affiliated with the Kets from the Yenisey River, while the Nganasans are separated from their linguistic neighbors, showing closer affinities with the Evenks and Yukagirs.
AB - Objectives: We examined autosomal genome-wide SNPs and Y-chromosome data from 15 Siberian and 12 reference populations to study the affinities of Siberian populations, and to address hypotheses about the origin of the Samoyed peoples. Methods: Samples were genotyped for 567 096 autosomal SNPs and 147 Y-chromosome polymorphic sites. For several analyses, we used 281 093 SNPs from the intersection of our data with publicly available ancient Siberian samples. To examine genetic relatedness among populations, we applied PCA, FST, TreeMix, and ADMIXTURE analyses. To explore the potential effect of demography and evolutionary processes, the distribution of ROH and IBD sharing within population were studied. Results: Analyses of autosomal and Y-chromosome data reveal high differentiation of the Siberian groups. The Siberian populations have a large proportion of their genome in ROH and IBD segments. Several populations (ie, Nganasans, Evenks, Yukagirs, and Koryaks) do not appear to have experienced admixture with other Siberian populations (ie, producing only positive f3), while for the other tested populations the composition of mixing sources always included Nganasans or Evenks. The Nganasans from the Taymyr Peninsula demonstrate the greatest level of shared shorter ROH and IBD with nearly all other Siberian populations. Conclusions: Autosomal SNP and Y-chromosome data demonstrate that Samoyedic populations differ significantly in their genetic composition. Genetic relationship is observed only between Forest and Tundra Nentsi. Selkups are affiliated with the Kets from the Yenisey River, while the Nganasans are separated from their linguistic neighbors, showing closer affinities with the Evenks and Yukagirs.
KW - MITOCHONDRIAL-DNA
KW - AGE
KW - HISTORY
KW - ADMIXTURE
KW - POLYMORPHISMS
KW - NGANASANS
KW - MIGRATION
KW - LANGUAGES
KW - ANCESTRY
KW - PATTERNS
KW - DNA, Ancient/analysis
KW - Humans
KW - Chromosomes, Human, Y/genetics
KW - Genetic Variation
KW - Siberia
KW - Linguistics
KW - Polymorphism, Single Nucleotide
KW - Human Migration
UR - http://www.scopus.com/inward/record.url?scp=85056152764&partnerID=8YFLogxK
U2 - 10.1002/ajhb.23194
DO - 10.1002/ajhb.23194
M3 - Article
C2 - 30408262
AN - SCOPUS:85056152764
VL - 30
JO - American Journal of Human Biology
JF - American Journal of Human Biology
SN - 1042-0533
IS - 6
M1 - 23194
ER -
ID: 17488113