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Shadow coat colour in American mink associated with a missense mutation in the KIT gene. / Manakhov, Andrey D.; Mintseva, Maria Yu; Andreeva, Tatiana V. et al.

In: Animal Genetics, Vol. 53, No. 4, 08.2022, p. 522-525.

Research output: Contribution to journal › Article › peer-review

Harvard

Manakhov, AD, Mintseva, MY, Andreeva, TV, Trapezov, OV & Rogaev, EI 2022, 'Shadow coat colour in American mink associated with a missense mutation in the KIT gene', Animal Genetics, vol. 53, no. 4, pp. 522-525. https://doi.org/10.1111/age.13202

APA

Manakhov, A. D., Mintseva, M. Y., Andreeva, T. V., Trapezov, O. V., & Rogaev, E. I. (2022). Shadow coat colour in American mink associated with a missense mutation in the KIT gene. Animal Genetics, 53(4), 522-525. https://doi.org/10.1111/age.13202

Vancouver

Manakhov AD, Mintseva MY, Andreeva TV, Trapezov OV, Rogaev EI. Shadow coat colour in American mink associated with a missense mutation in the KIT gene. Animal Genetics. 2022 Aug;53(4):522-525. Epub 2022 Apr 28. doi: 10.1111/age.13202

Author

Manakhov, Andrey D. ; Mintseva, Maria Yu ; Andreeva, Tatiana V. et al. / Shadow coat colour in American mink associated with a missense mutation in the KIT gene. In: Animal Genetics. 2022 ; Vol. 53, No. 4. pp. 522-525.

BibTeX

@article{c99d18eb9b1f477b94fe18b73cc39c7d,
title = "Shadow coat colour in American mink associated with a missense mutation in the KIT gene",
abstract = "The classical genetic analysis describes more 35 mutations that are involved in the formation of the American mink (Neovison vison) fur colour phenotype. To date, only eight of these mutations have been linked to specific genes. Shadow is a member of the commercially valuable Black cross colour family. Here, we performed whole-genome sequencing of the American mink with a Shadow Silverblue (Sh/+ p/p) phenotype. We identified a missense mutation (c.2374 G>T) in the gene encoding the KIT proto-oncogene, receptor tyrosine kinase gene (KIT), which plays a critical role in melanogenesis as well as in the survival, growth and development of other cell types. The reported mutation results in amino acid substitution p.Asp792Tyr in a highly conserved catalytic loop of the KIT protein.",
keywords = "American mink, KIT, Shadow, Hair Color/genetics, Phenotype, Animals, Mink/genetics, Color, Mutation, Mutation, Missense",
author = "Manakhov, {Andrey D.} and Mintseva, {Maria Yu} and Andreeva, {Tatiana V.} and Trapezov, {Oleg V.} and Rogaev, {Evgeny I.}",
note = "Funding Information: The study was supported by Sirius University of Science and Technology (genomic data analysis and gene identification). Collection of the animal breeds was conducted in a special animal breed facility that is supported by the Institute of Cytology and Genetics SB RAS project no. 0259‐2021‐0015 by a grant to O.V.T. Publisher Copyright: {\textcopyright} 2022 Stichting International Foundation for Animal Genetics.",
year = "2022",
month = aug,
doi = "10.1111/age.13202",
language = "English",
volume = "53",
pages = "522--525",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Shadow coat colour in American mink associated with a missense mutation in the KIT gene

AU - Manakhov, Andrey D.

AU - Mintseva, Maria Yu

AU - Andreeva, Tatiana V.

AU - Trapezov, Oleg V.

AU - Rogaev, Evgeny I.

N1 - Funding Information: The study was supported by Sirius University of Science and Technology (genomic data analysis and gene identification). Collection of the animal breeds was conducted in a special animal breed facility that is supported by the Institute of Cytology and Genetics SB RAS project no. 0259‐2021‐0015 by a grant to O.V.T. Publisher Copyright: © 2022 Stichting International Foundation for Animal Genetics.

PY - 2022/8

Y1 - 2022/8

N2 - The classical genetic analysis describes more 35 mutations that are involved in the formation of the American mink (Neovison vison) fur colour phenotype. To date, only eight of these mutations have been linked to specific genes. Shadow is a member of the commercially valuable Black cross colour family. Here, we performed whole-genome sequencing of the American mink with a Shadow Silverblue (Sh/+ p/p) phenotype. We identified a missense mutation (c.2374 G>T) in the gene encoding the KIT proto-oncogene, receptor tyrosine kinase gene (KIT), which plays a critical role in melanogenesis as well as in the survival, growth and development of other cell types. The reported mutation results in amino acid substitution p.Asp792Tyr in a highly conserved catalytic loop of the KIT protein.

AB - The classical genetic analysis describes more 35 mutations that are involved in the formation of the American mink (Neovison vison) fur colour phenotype. To date, only eight of these mutations have been linked to specific genes. Shadow is a member of the commercially valuable Black cross colour family. Here, we performed whole-genome sequencing of the American mink with a Shadow Silverblue (Sh/+ p/p) phenotype. We identified a missense mutation (c.2374 G>T) in the gene encoding the KIT proto-oncogene, receptor tyrosine kinase gene (KIT), which plays a critical role in melanogenesis as well as in the survival, growth and development of other cell types. The reported mutation results in amino acid substitution p.Asp792Tyr in a highly conserved catalytic loop of the KIT protein.

KW - American mink

KW - KIT

KW - Shadow

KW - Hair Color/genetics

KW - Phenotype

KW - Animals

KW - Mink/genetics

KW - Color

KW - Mutation

KW - Mutation, Missense

UR - http://www.scopus.com/inward/record.url?scp=85128962308&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/ca1cc8f3-053b-36d6-bb2e-e824a156b399/

U2 - 10.1111/age.13202

DO - 10.1111/age.13202

M3 - Article

C2 - 35481560

AN - SCOPUS:85128962308

VL - 53

SP - 522

EP - 525

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 4

ER -

ID: 36030388