Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment. / dos Santos, Bruna E.; Giacomini, Ana C.V.V.; Marcon, Leticia et al.
In: Neuroscience Letters, Vol. 759, 135993, 10.08.2021.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment
AU - dos Santos, Bruna E.
AU - Giacomini, Ana C.V.V.
AU - Marcon, Leticia
AU - Demin, Konstantin A.
AU - Strekalova, Tatyana
AU - de Abreu, Murilo S.
AU - Kalueff, Allan V.
N1 - Funding Information: ACVVG is supported by the Research Support Foundation of the State of Rio Grande do Sul (FAPERGS) research fellowships 19/2551-0001-669-7 . AVK is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China). KAD is supported by the President of Russia Graduate Fellowship , state budgetary research project 51130521 from SPSU and the Special Rector’s Fellowship for SPSU students. The laboratory is supported by the budgetary state funding from the Ministry of Healthcare of Russian Federation (project 121040200141-4). The project was also supported in part by Sirius University (Sochi, Russia). TGA/AVK collaborative study is supported by the Russian Science Foundation (RSF) grant 20-65-46006 . The authors thank Sirlei Cazarotto (University of Passo Fundo, Brazil) for her assistance with experimental procedures. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: ACVVG is supported by the Research Support Foundation of the State of Rio Grande do Sul (FAPERGS) research fellowships 19/2551-0001-669-7. AVK is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China). KAD is supported by the President of Russia Graduate Fellowship, state budgetary research project 51130521 from SPSU and the Special Rector's Fellowship for SPSU students. The laboratory is supported by the budgetary state funding from the Ministry of Healthcare of Russian Federation (project 121040200141-4). The project was also supported in part by Sirius University (Sochi, Russia). TGA/AVK collaborative study is supported by the Russian Science Foundation (RSF) grant 20-65-46006. The authors thank Sirlei Cazarotto (University of Passo Fundo, Brazil) for her assistance with experimental procedures. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2021 Elsevier B.V.
PY - 2021/8/10
Y1 - 2021/8/10
N2 - Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-μM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.
AB - Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-μM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.
KW - Anxiety-like behavior
KW - Locomotion
KW - Scopolamine
KW - Sex differences
KW - Temperament
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85108336314&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2021.135993
DO - 10.1016/j.neulet.2021.135993
M3 - Article
C2 - 34058290
AN - SCOPUS:85108336314
VL - 759
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
M1 - 135993
ER -
ID: 33980187