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Severe cases of seasonal influenza in Russia in 2017-2018. / Kolosova, Natalia P.; Ilyicheva, Tatyana N.; Danilenko, Alexey V. et al.

In: PLoS ONE, Vol. 14, No. 7, e0220401, 01.07.2019, p. e0220401.

Research output: Contribution to journalArticlepeer-review

Harvard

Kolosova, NP, Ilyicheva, TN, Danilenko, AV, Bulanovich, JA, Svyatchenko, SV, Durymanov, AG, Goncharova, NI, Gudymo, AS, Shvalov, AN, Susloparov, IM, Marchenko, VY, Tregubchak, TV, Gavrilova, EV, Maksyutov, RA & Ryzhikov, AB 2019, 'Severe cases of seasonal influenza in Russia in 2017-2018', PLoS ONE, vol. 14, no. 7, e0220401, pp. e0220401. https://doi.org/10.1371/journal.pone.0220401

APA

Kolosova, N. P., Ilyicheva, T. N., Danilenko, A. V., Bulanovich, J. A., Svyatchenko, S. V., Durymanov, A. G., Goncharova, N. I., Gudymo, A. S., Shvalov, A. N., Susloparov, I. M., Marchenko, V. Y., Tregubchak, T. V., Gavrilova, E. V., Maksyutov, R. A., & Ryzhikov, A. B. (2019). Severe cases of seasonal influenza in Russia in 2017-2018. PLoS ONE, 14(7), e0220401. [e0220401]. https://doi.org/10.1371/journal.pone.0220401

Vancouver

Kolosova NP, Ilyicheva TN, Danilenko AV, Bulanovich JA, Svyatchenko SV, Durymanov AG et al. Severe cases of seasonal influenza in Russia in 2017-2018. PLoS ONE. 2019 Jul 1;14(7):e0220401. e0220401. doi: 10.1371/journal.pone.0220401

Author

Kolosova, Natalia P. ; Ilyicheva, Tatyana N. ; Danilenko, Alexey V. et al. / Severe cases of seasonal influenza in Russia in 2017-2018. In: PLoS ONE. 2019 ; Vol. 14, No. 7. pp. e0220401.

BibTeX

@article{9db06a11fe884ac2a605302f72e473c2,
title = "Severe cases of seasonal influenza in Russia in 2017-2018",
abstract = "The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017. During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza cases, including selected viral isolates and viruses analyzed directly from the original clinical material, were genetically characterized. The analyzed A(H1N1)pdm09 viruses belonged to clade 6B.1, B/Yamagata-like viruses belonged to clade 3, and B/Victoria-like viruses belonged to clade 1A and they were antigenically similar to the corresponding vaccine strains. A(H3N2) viruses belonged to clade 3C.2a and were difficult to characterize antigenically and the analysis indicated antigenic differences from the corresponding egg-grown vaccine strain. The next generation sequencing revealed the presence of D222/G/N polymorphism in the hemagglutinin gene in 32% of the analyzed A(H1N1)pdm09 lethal cases. This study demonstrated the importance of monitoring D222G/N polymorphism, including detection of minor viral variants with the mutations, in the hemagglutinin gene of A(H1N1)pdm09 for epidemiological surveillance. One strain of influenza virus A(H1N1)pdm09 was resistant to oseltamivir and had the H275Y amino acid substitution in the NA protein. All other isolates were susceptible to NA inhibitors. Prior to the 2017-2018 epidemic season, 67.4 million people were vaccinated, which accounted for 46.6% of the country's population. Just before the epidemic season 33-47% and 24-30% of blood sera samples collected within the territory of Russia showed the presence of protective antibody titers against vaccine strains of influenza A and influenza B/Victoria-like, respectively. Mass vaccination of the population had evidently reduced the severity of the flu epidemic during the 2017-2018 influenza epidemic season in Russia.",
keywords = "UNITED-STATES, VIRUSES, ASIA",
author = "Kolosova, {Natalia P.} and Ilyicheva, {Tatyana N.} and Danilenko, {Alexey V.} and Bulanovich, {Julia A.} and Svyatchenko, {Svetlana V.} and Durymanov, {Alexander G.} and Goncharova, {Natalia I.} and Gudymo, {Andrei S.} and Shvalov, {Alexander N.} and Susloparov, {Ivan M.} and Marchenko, {Vasiliy Y.} and Tregubchak, {Tatyana V.} and Gavrilova, {Elena V.} and Maksyutov, {Rinat A.} and Ryzhikov, {Alexander B.}",
year = "2019",
month = jul,
day = "1",
doi = "10.1371/journal.pone.0220401",
language = "English",
volume = "14",
pages = "e0220401",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Severe cases of seasonal influenza in Russia in 2017-2018

AU - Kolosova, Natalia P.

AU - Ilyicheva, Tatyana N.

AU - Danilenko, Alexey V.

AU - Bulanovich, Julia A.

AU - Svyatchenko, Svetlana V.

AU - Durymanov, Alexander G.

AU - Goncharova, Natalia I.

AU - Gudymo, Andrei S.

AU - Shvalov, Alexander N.

AU - Susloparov, Ivan M.

AU - Marchenko, Vasiliy Y.

AU - Tregubchak, Tatyana V.

AU - Gavrilova, Elena V.

AU - Maksyutov, Rinat A.

AU - Ryzhikov, Alexander B.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017. During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza cases, including selected viral isolates and viruses analyzed directly from the original clinical material, were genetically characterized. The analyzed A(H1N1)pdm09 viruses belonged to clade 6B.1, B/Yamagata-like viruses belonged to clade 3, and B/Victoria-like viruses belonged to clade 1A and they were antigenically similar to the corresponding vaccine strains. A(H3N2) viruses belonged to clade 3C.2a and were difficult to characterize antigenically and the analysis indicated antigenic differences from the corresponding egg-grown vaccine strain. The next generation sequencing revealed the presence of D222/G/N polymorphism in the hemagglutinin gene in 32% of the analyzed A(H1N1)pdm09 lethal cases. This study demonstrated the importance of monitoring D222G/N polymorphism, including detection of minor viral variants with the mutations, in the hemagglutinin gene of A(H1N1)pdm09 for epidemiological surveillance. One strain of influenza virus A(H1N1)pdm09 was resistant to oseltamivir and had the H275Y amino acid substitution in the NA protein. All other isolates were susceptible to NA inhibitors. Prior to the 2017-2018 epidemic season, 67.4 million people were vaccinated, which accounted for 46.6% of the country's population. Just before the epidemic season 33-47% and 24-30% of blood sera samples collected within the territory of Russia showed the presence of protective antibody titers against vaccine strains of influenza A and influenza B/Victoria-like, respectively. Mass vaccination of the population had evidently reduced the severity of the flu epidemic during the 2017-2018 influenza epidemic season in Russia.

AB - The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017. During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza cases, including selected viral isolates and viruses analyzed directly from the original clinical material, were genetically characterized. The analyzed A(H1N1)pdm09 viruses belonged to clade 6B.1, B/Yamagata-like viruses belonged to clade 3, and B/Victoria-like viruses belonged to clade 1A and they were antigenically similar to the corresponding vaccine strains. A(H3N2) viruses belonged to clade 3C.2a and were difficult to characterize antigenically and the analysis indicated antigenic differences from the corresponding egg-grown vaccine strain. The next generation sequencing revealed the presence of D222/G/N polymorphism in the hemagglutinin gene in 32% of the analyzed A(H1N1)pdm09 lethal cases. This study demonstrated the importance of monitoring D222G/N polymorphism, including detection of minor viral variants with the mutations, in the hemagglutinin gene of A(H1N1)pdm09 for epidemiological surveillance. One strain of influenza virus A(H1N1)pdm09 was resistant to oseltamivir and had the H275Y amino acid substitution in the NA protein. All other isolates were susceptible to NA inhibitors. Prior to the 2017-2018 epidemic season, 67.4 million people were vaccinated, which accounted for 46.6% of the country's population. Just before the epidemic season 33-47% and 24-30% of blood sera samples collected within the territory of Russia showed the presence of protective antibody titers against vaccine strains of influenza A and influenza B/Victoria-like, respectively. Mass vaccination of the population had evidently reduced the severity of the flu epidemic during the 2017-2018 influenza epidemic season in Russia.

KW - UNITED-STATES

KW - VIRUSES

KW - ASIA

UR - http://www.scopus.com/inward/record.url?scp=85070770468&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0220401

DO - 10.1371/journal.pone.0220401

M3 - Article

C2 - 31356626

AN - SCOPUS:85070770468

VL - 14

SP - e0220401

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 7

M1 - e0220401

ER -

ID: 21257706