Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
Selection of an optimal method for sterilization of the medical grade biodegradable polymers. / Samokhin, Alexander G.; Tkachenko, Vadim O.; Kuznetsov, Vasily A. et al.
Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018: Proceedings of the II International. ed. / Sougata Santra; Grigory V. Zyryanov; Leila K. Sadieva. Vol. 2063 American Institute of Physics Inc., 2019. 030017.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
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TY - GEN
T1 - Selection of an optimal method for sterilization of the medical grade biodegradable polymers
AU - Samokhin, Alexander G.
AU - Tkachenko, Vadim O.
AU - Kuznetsov, Vasily A.
AU - Zemlyakova, Ekaterina O.
AU - Nesterov, Denis V.
AU - Larionov, Petr M.
AU - Pestov, Alexander V.
PY - 2019/1/11
Y1 - 2019/1/11
N2 - Aim of this study was to assess possible influence of chitosan-based gels (without cross-linker treatment and cross-linked with one of the next substances - glutaraldehyde, hexamethylene diisocyanate or oxidized alginate) onto live tissues in in vivo animal model and evaluate and select optimal sterilization method of such biodegradable materials. Sterilization of all chitosan gel samples were performed using three different methods: steam sterilization, low-temperature hydrogen peroxide plasma and radiation sterilization. The best swelling degree values were obtained for chitosan gels cross-linked with glutaraldehyde or hexamethylene diisocyanate. Further in vivo animal model 14-day evaluation showed no toxic, immunosuppression or sensitization effects nor dystrophic and autoimmune changes in live tissues that have been directed in contact with implanted polymer. Among all three evaluated sterilization methods the best one was the radiation sterilization in terms of preserving the desired characteristics of swelling and minimal changes in chemical composition and properties of sterilized materials, even with 25 kGy absorbed dose that allows sterility assurance level at 10-6 to be achieved.
AB - Aim of this study was to assess possible influence of chitosan-based gels (without cross-linker treatment and cross-linked with one of the next substances - glutaraldehyde, hexamethylene diisocyanate or oxidized alginate) onto live tissues in in vivo animal model and evaluate and select optimal sterilization method of such biodegradable materials. Sterilization of all chitosan gel samples were performed using three different methods: steam sterilization, low-temperature hydrogen peroxide plasma and radiation sterilization. The best swelling degree values were obtained for chitosan gels cross-linked with glutaraldehyde or hexamethylene diisocyanate. Further in vivo animal model 14-day evaluation showed no toxic, immunosuppression or sensitization effects nor dystrophic and autoimmune changes in live tissues that have been directed in contact with implanted polymer. Among all three evaluated sterilization methods the best one was the radiation sterilization in terms of preserving the desired characteristics of swelling and minimal changes in chemical composition and properties of sterilized materials, even with 25 kGy absorbed dose that allows sterility assurance level at 10-6 to be achieved.
UR - http://www.scopus.com/inward/record.url?scp=85060445902&partnerID=8YFLogxK
U2 - 10.1063/1.5087325
DO - 10.1063/1.5087325
M3 - Conference contribution
AN - SCOPUS:85060445902
VL - 2063
BT - Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018
A2 - Santra, Sougata
A2 - Zyryanov, Grigory V.
A2 - Sadieva, Leila K.
PB - American Institute of Physics Inc.
T2 - 2nd International conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018
Y2 - 15 November 2018 through 17 November 2018
ER -
ID: 18297318