Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium

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Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium. / Perevalova, Alina M.; Kobelev, Vyacheslav S.; Sisakyan, Virab G. et al.

In: Biochemistry (Moscow), Vol. 87, No. 11, 11.2022, p. 1310-1326.

Research output: Contribution to journal › Review article › peer-review

Author

Perevalova, Alina M. ; Kobelev, Vyacheslav S. ; Sisakyan, Virab G. et al. / Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium. In: Biochemistry (Moscow). 2022 ; Vol. 87, No. 11. pp. 1310-1326.

BibTeX

@article{4effa87e91f64cab8dcf5074d83c3679,

title = "Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium",

abstract = "Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse – PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors – endometrial cancer.",

keywords = "endometrial cancer, endometrial hyperplasia, gene regulation, PTEN",

author = "Perevalova, {Alina M.} and Kobelev, {Vyacheslav S.} and Sisakyan, {Virab G.} and Gulyaeva, {Lyudmila F.} and Pustylnyak, {Vladimir O.}",

note = "Publisher Copyright: {\textcopyright} 2022, Pleiades Publishing, Ltd.",

year = "2022",

month = nov,

doi = "10.1134/S0006297922110104",

language = "English",

volume = "87",

pages = "1310--1326",

journal = "Biochemistry (Moscow)",

issn = "0006-2979",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "11",

}

RIS

TY - JOUR

T1 - Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium

AU - Perevalova, Alina M.

AU - Kobelev, Vyacheslav S.

AU - Sisakyan, Virab G.

AU - Gulyaeva, Lyudmila F.

AU - Pustylnyak, Vladimir O.

PY - 2022/11

Y1 - 2022/11

N2 - Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse – PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors – endometrial cancer.

AB - Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse – PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors – endometrial cancer.

KW - endometrial cancer

KW - endometrial hyperplasia

KW - gene regulation

KW - PTEN

UR - http://www.scopus.com/inward/record.url?scp=85142153139&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/d072c0bd-ec5a-33db-aab0-9d7ccfc3ea59/

U2 - 10.1134/S0006297922110104

DO - 10.1134/S0006297922110104

M3 - Review article

C2 - 36509719

AN - SCOPUS:85142153139

VL - 87

SP - 1310

EP - 1326

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 11

ER -

ID: 39701891