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Regulatory SNPs and their widespread effects on the transcriptome. / Merkulov, Vasily M.; Leberfarb, Elena Yu; Merkulova, Tatiana I.

In: Journal of Biosciences, Vol. 43, No. 5, 01.12.2018, p. 1069-1075.

Research output: Contribution to journal › Review article › peer-review

Harvard

Merkulov, VM, Leberfarb, EY & Merkulova, TI 2018, 'Regulatory SNPs and their widespread effects on the transcriptome', Journal of Biosciences, vol. 43, no. 5, pp. 1069-1075. https://doi.org/10.1007/s12038-018-9817-7

APA

Merkulov, V. M., Leberfarb, E. Y., & Merkulova, T. I. (2018). Regulatory SNPs and their widespread effects on the transcriptome. Journal of Biosciences, 43(5), 1069-1075. https://doi.org/10.1007/s12038-018-9817-7

Vancouver

Merkulov VM, Leberfarb EY, Merkulova TI. Regulatory SNPs and their widespread effects on the transcriptome. Journal of Biosciences. 2018 Dec 1;43(5):1069-1075. doi: 10.1007/s12038-018-9817-7

Author

Merkulov, Vasily M. ; Leberfarb, Elena Yu ; Merkulova, Tatiana I. / Regulatory SNPs and their widespread effects on the transcriptome. In: Journal of Biosciences. 2018 ; Vol. 43, No. 5. pp. 1069-1075.

BibTeX

@article{08307684cc4147708cfb37daa4ac0da1,
title = "Regulatory SNPs and their widespread effects on the transcriptome",
abstract = "Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor for phenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes for the identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, components of signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complex gene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptional regulation across the genome.",
keywords = "Downstream effects, gene expression, regulatory SNPs (rSNPs), transcriptome, ACTIVATION, MYOCARDIAL-INFARCTION, ZNF804A, SCHIZOPHRENIA, BIPOLAR DISORDER, COLORECTAL-CANCER, PROSTATE-CANCER, GENE-EXPRESSION, RISK VARIANT, GENOME-WIDE ASSOCIATION",
author = "Merkulov, {Vasily M.} and Leberfarb, {Elena Yu} and Merkulova, {Tatiana I.}",
note = "Publisher Copyright: {\textcopyright} 2018, Indian Academy of Sciences.",
year = "2018",
month = dec,
day = "1",
doi = "10.1007/s12038-018-9817-7",
language = "English",
volume = "43",
pages = "1069--1075",
journal = "Journal of Biosciences",
issn = "0250-5991",
publisher = "Springer India",
number = "5",

}

RIS

TY - JOUR

T1 - Regulatory SNPs and their widespread effects on the transcriptome

AU - Merkulov, Vasily M.

AU - Leberfarb, Elena Yu

AU - Merkulova, Tatiana I.

N1 - Publisher Copyright: © 2018, Indian Academy of Sciences.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor for phenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes for the identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, components of signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complex gene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptional regulation across the genome.

AB - Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor for phenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes for the identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, components of signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complex gene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptional regulation across the genome.

KW - Downstream effects

KW - gene expression

KW - regulatory SNPs (rSNPs)

KW - transcriptome

KW - ACTIVATION

KW - MYOCARDIAL-INFARCTION

KW - ZNF804A

KW - SCHIZOPHRENIA

KW - BIPOLAR DISORDER

KW - COLORECTAL-CANCER

KW - PROSTATE-CANCER

KW - GENE-EXPRESSION

KW - RISK VARIANT

KW - GENOME-WIDE ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85054482351&partnerID=8YFLogxK

U2 - 10.1007/s12038-018-9817-7

DO - 10.1007/s12038-018-9817-7

M3 - Review article

AN - SCOPUS:85054482351

VL - 43

SP - 1069

EP - 1075

JO - Journal of Biosciences

JF - Journal of Biosciences

SN - 0250-5991

IS - 5

ER -

ID: 17039860