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Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022. / Kolosova, Natalia P; Ilyicheva, Tatiana N; Unguryan, Vasily V et al.

In: Pathogens, Vol. 11, No. 11, 1388, 21.11.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Kolosova, NP, Ilyicheva, TN, Unguryan, VV, Danilenko, AV, Svyatchenko, SV, Onhonova, GS, Goncharova, NI, Kosenko, MN, Gudymo, AS, Marchenko, VY, Shvalov, AN, Susloparov, IM, Tregubchak, TV, Gavrilova, EV, Maksyutov, RA & Ryzhikov, AB 2022, 'Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022', Pathogens, vol. 11, no. 11, 1388. https://doi.org/10.3390/pathogens11111388

APA

Kolosova, N. P., Ilyicheva, T. N., Unguryan, V. V., Danilenko, A. V., Svyatchenko, S. V., Onhonova, G. S., Goncharova, N. I., Kosenko, M. N., Gudymo, A. S., Marchenko, V. Y., Shvalov, A. N., Susloparov, I. M., Tregubchak, T. V., Gavrilova, E. V., Maksyutov, R. A., & Ryzhikov, A. B. (2022). Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022. Pathogens, 11(11), [1388]. https://doi.org/10.3390/pathogens11111388

Vancouver

Kolosova NP, Ilyicheva TN, Unguryan VV, Danilenko AV, Svyatchenko SV, Onhonova GS et al. Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022. Pathogens. 2022 Nov 21;11(11):1388. doi: 10.3390/pathogens11111388

Author

Kolosova, Natalia P ; Ilyicheva, Tatiana N ; Unguryan, Vasily V et al. / Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022. In: Pathogens. 2022 ; Vol. 11, No. 11.

BibTeX

@article{c46d39ca34fa4dd5949f7165dbc9a28b,
title = "Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022",
abstract = "The circulation of seasonal influenza in 2020-2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021-2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021-2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6'-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis.",
author = "Kolosova, {Natalia P} and Ilyicheva, {Tatiana N} and Unguryan, {Vasily V} and Danilenko, {Alexey V} and Svyatchenko, {Svetlana V} and Onhonova, {Galina S} and Goncharova, {Natalia I} and Kosenko, {Maksim N} and Gudymo, {Andrey S} and Marchenko, {Vasiliy Y} and Shvalov, {Alexander N} and Susloparov, {Ivan M} and Tregubchak, {Tatiana V} and Gavrilova, {Elena V} and Maksyutov, {Rinat A} and Ryzhikov, {Alexander B}",
note = "Funding: The work was supported by State Assignment, Rospotrebnadzor, and by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2021-1355 dated 12 October 2021) as part of the implementation of certain activities of the Federal Scientific and Technical Program for the Development of Synchrotron and Neutron Research and Research Infrastructure for 2019–2027.",
year = "2022",
month = nov,
day = "21",
doi = "10.3390/pathogens11111388",
language = "English",
volume = "11",
journal = "Pathogens",
issn = "2076-0817",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

RIS

TY - JOUR

T1 - Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022

AU - Kolosova, Natalia P

AU - Ilyicheva, Tatiana N

AU - Unguryan, Vasily V

AU - Danilenko, Alexey V

AU - Svyatchenko, Svetlana V

AU - Onhonova, Galina S

AU - Goncharova, Natalia I

AU - Kosenko, Maksim N

AU - Gudymo, Andrey S

AU - Marchenko, Vasiliy Y

AU - Shvalov, Alexander N

AU - Susloparov, Ivan M

AU - Tregubchak, Tatiana V

AU - Gavrilova, Elena V

AU - Maksyutov, Rinat A

AU - Ryzhikov, Alexander B

N1 - Funding: The work was supported by State Assignment, Rospotrebnadzor, and by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2021-1355 dated 12 October 2021) as part of the implementation of certain activities of the Federal Scientific and Technical Program for the Development of Synchrotron and Neutron Research and Research Infrastructure for 2019–2027.

PY - 2022/11/21

Y1 - 2022/11/21

N2 - The circulation of seasonal influenza in 2020-2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021-2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021-2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6'-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis.

AB - The circulation of seasonal influenza in 2020-2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021-2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021-2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6'-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85149521224&origin=inward&txGid=26cb2b157b6ff9dda95718fdd593cd97

UR - https://www.mendeley.com/catalogue/0ffc53fc-8c39-3bd9-afb0-291d0c04802e/

U2 - 10.3390/pathogens11111388

DO - 10.3390/pathogens11111388

M3 - Article

C2 - 36422639

VL - 11

JO - Pathogens

JF - Pathogens

SN - 2076-0817

IS - 11

M1 - 1388

ER -

ID: 43854530