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Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. / Kukekova, Anna V.; Johnson, Jennifer L.; Xiang, Xueyan et al.

In: Nature Ecology and Evolution, Vol. 2, No. 9, 01.09.2018, p. 1479-1491.

Research output: Contribution to journal › Article › peer-review

Harvard

Kukekova, AV, Johnson, JL, Xiang, X, Feng, S, Liu, S, Rando, HM, Kharlamova, AV, Herbeck, Y, Serdyukova, NA, Xiong, Z, Beklemischeva, V, Koepfli, KP, Gulevich, RG, Vladimirova, AV, Hekman, JP, Perelman, PL, Graphodatsky, AS, O’Brien, SJ, Wang, X, Clark, AG, Acland, GM, Trut, LN & Zhang, G 2018, 'Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours', Nature Ecology and Evolution, vol. 2, no. 9, pp. 1479-1491. https://doi.org/10.1038/s41559-018-0611-6

APA

Kukekova, A. V., Johnson, J. L., Xiang, X., Feng, S., Liu, S., Rando, H. M., Kharlamova, A. V., Herbeck, Y., Serdyukova, N. A., Xiong, Z., Beklemischeva, V., Koepfli, K. P., Gulevich, R. G., Vladimirova, A. V., Hekman, J. P., Perelman, P. L., Graphodatsky, A. S., O’Brien, S. J., Wang, X., ... Zhang, G. (2018). Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. Nature Ecology and Evolution, 2(9), 1479-1491. https://doi.org/10.1038/s41559-018-0611-6

Vancouver

Kukekova AV, Johnson JL, Xiang X, Feng S, Liu S, Rando HM et al. Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. Nature Ecology and Evolution. 2018 Sept 1;2(9):1479-1491. doi: 10.1038/s41559-018-0611-6

Author

Kukekova, Anna V. ; Johnson, Jennifer L. ; Xiang, Xueyan et al. / Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. In: Nature Ecology and Evolution. 2018 ; Vol. 2, No. 9. pp. 1479-1491.

BibTeX

@article{acfb858a78ec4800ba686687835fe03a,
title = "Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours",
abstract = "Strains of red fox (Vulpes vulpes) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as the Russian farm-fox experiment. Here we sequenced and assembled the red fox genome and re-sequenced a subset of foxes from the tame, aggressive and conventional farm-bred populations to identify genomic regions associated with the response to selection for behaviour. Analysis of the re-sequenced genomes identified 103 regions with either significantly decreased heterozygosity in one of the three populations or increased divergence between the populations. A strong positional candidate gene for tame behaviour was highlighted: SorCS1, which encodes the main trafficking protein for AMPA glutamate receptors and neurexins and suggests a role for synaptic plasticity in fox domestication. Other regions identified as likely to have been under selection in foxes include genes implicated in human neurological disorders, mouse behaviour and dog domestication. The fox represents a powerful model for the genetic analysis of affiliative and aggressive behaviours that can benefit genetic studies of behaviour in dogs and other mammals, including humans.",
author = "Kukekova, {Anna V.} and Johnson, {Jennifer L.} and Xueyan Xiang and Shaohong Feng and Shiping Liu and Rando, {Halie M.} and Kharlamova, {Anastasiya V.} and Yury Herbeck and Serdyukova, {Natalya A.} and Zijun Xiong and Violetta Beklemischeva and Koepfli, {Klaus Peter} and Gulevich, {Rimma G.} and Vladimirova, {Anastasiya V.} and Hekman, {Jessica P.} and Perelman, {Polina L.} and Graphodatsky, {Aleksander S.} and O{\textquoteright}Brien, {Stephen J.} and Xu Wang and Clark, {Andrew G.} and Acland, {Gregory M.} and Trut, {Lyudmila N.} and Guojie Zhang",
note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = sep,
day = "1",
doi = "10.1038/s41559-018-0611-6",
language = "English",
volume = "2",
pages = "1479--1491",
journal = "Nature Ecology and Evolution",
issn = "2397-334X",
publisher = "Nature Publishing Group",
number = "9",

}

RIS

TY - JOUR

T1 - Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours

AU - Kukekova, Anna V.

AU - Johnson, Jennifer L.

AU - Xiang, Xueyan

AU - Feng, Shaohong

AU - Liu, Shiping

AU - Rando, Halie M.

AU - Kharlamova, Anastasiya V.

AU - Herbeck, Yury

AU - Serdyukova, Natalya A.

AU - Xiong, Zijun

AU - Beklemischeva, Violetta

AU - Koepfli, Klaus Peter

AU - Gulevich, Rimma G.

AU - Vladimirova, Anastasiya V.

AU - Hekman, Jessica P.

AU - Perelman, Polina L.

AU - Graphodatsky, Aleksander S.

AU - O’Brien, Stephen J.

AU - Wang, Xu

AU - Clark, Andrew G.

AU - Acland, Gregory M.

AU - Trut, Lyudmila N.

AU - Zhang, Guojie

N1 - Publisher Copyright: © 2018, The Author(s).

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Strains of red fox (Vulpes vulpes) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as the Russian farm-fox experiment. Here we sequenced and assembled the red fox genome and re-sequenced a subset of foxes from the tame, aggressive and conventional farm-bred populations to identify genomic regions associated with the response to selection for behaviour. Analysis of the re-sequenced genomes identified 103 regions with either significantly decreased heterozygosity in one of the three populations or increased divergence between the populations. A strong positional candidate gene for tame behaviour was highlighted: SorCS1, which encodes the main trafficking protein for AMPA glutamate receptors and neurexins and suggests a role for synaptic plasticity in fox domestication. Other regions identified as likely to have been under selection in foxes include genes implicated in human neurological disorders, mouse behaviour and dog domestication. The fox represents a powerful model for the genetic analysis of affiliative and aggressive behaviours that can benefit genetic studies of behaviour in dogs and other mammals, including humans.

AB - Strains of red fox (Vulpes vulpes) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as the Russian farm-fox experiment. Here we sequenced and assembled the red fox genome and re-sequenced a subset of foxes from the tame, aggressive and conventional farm-bred populations to identify genomic regions associated with the response to selection for behaviour. Analysis of the re-sequenced genomes identified 103 regions with either significantly decreased heterozygosity in one of the three populations or increased divergence between the populations. A strong positional candidate gene for tame behaviour was highlighted: SorCS1, which encodes the main trafficking protein for AMPA glutamate receptors and neurexins and suggests a role for synaptic plasticity in fox domestication. Other regions identified as likely to have been under selection in foxes include genes implicated in human neurological disorders, mouse behaviour and dog domestication. The fox represents a powerful model for the genetic analysis of affiliative and aggressive behaviours that can benefit genetic studies of behaviour in dogs and other mammals, including humans.

UR - http://www.scopus.com/inward/record.url?scp=85051462033&partnerID=8YFLogxK

U2 - 10.1038/s41559-018-0611-6

DO - 10.1038/s41559-018-0611-6

M3 - Article

C2 - 30082739

AN - SCOPUS:85051462033

VL - 2

SP - 1479

EP - 1491

JO - Nature Ecology and Evolution

JF - Nature Ecology and Evolution

SN - 2397-334X

IS - 9

ER -

ID: 16257822