Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
Reconstruction of Dementia Gene Network Using Online Bioinformatics Tools. / Kovalev, Sergey S.; Dergilev, Arthur I.; Orlov, Yuriy L. et al.
Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 215-219 9214618 (Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
}
TY - GEN
T1 - Reconstruction of Dementia Gene Network Using Online Bioinformatics Tools
AU - Kovalev, Sergey S.
AU - Dergilev, Arthur I.
AU - Orlov, Yuriy L.
AU - Fateev, Oleg D.
AU - Kavai-Ool, Urana N.
N1 - Publisher Copyright: © 2020 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - In this work, the set of genes associated with mental diseases such as dementia was examined and analyzed using previously developed gene ontology annotation tools and databases. The aim of the study is to describe the gene ontologies and molecular mechanisms of dementia based on the analysis of the related human gene set using available bioinformatics databases, annotation and recent publications. Dementia is a chronic, general, usually irreversible decrease in cognitive function that affects all aspects of cognitive activity. The enriched gene ontology categories for dementia genes are regulation of neuronal death and cell death, cellular components organization, and cognition. A high connectivity of genes and their products was discovered when studying the structure of the gene network.
AB - In this work, the set of genes associated with mental diseases such as dementia was examined and analyzed using previously developed gene ontology annotation tools and databases. The aim of the study is to describe the gene ontologies and molecular mechanisms of dementia based on the analysis of the related human gene set using available bioinformatics databases, annotation and recent publications. Dementia is a chronic, general, usually irreversible decrease in cognitive function that affects all aspects of cognitive activity. The enriched gene ontology categories for dementia genes are regulation of neuronal death and cell death, cellular components organization, and cognition. A high connectivity of genes and their products was discovered when studying the structure of the gene network.
KW - bioinformatics
KW - dementia
KW - gene networks
KW - gene ontologies
KW - medical genomics
UR - http://www.scopus.com/inward/record.url?scp=85094811967&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=45218995
U2 - 10.1109/CSGB51356.2020.9214618
DO - 10.1109/CSGB51356.2020.9214618
M3 - Conference contribution
AN - SCOPUS:85094811967
T3 - Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
SP - 215
EP - 219
BT - Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
Y2 - 6 July 2020 through 10 July 2020
ER -
ID: 25841308